Evidence map›Paper›PMID 34440112›Full record

ReviewBiomedicines2021

Surgical Management of Adrenocortical Carcinoma: Current Highlights.

Giuseppe Cavallaro, Mariarita Tarallo, Ambra Chiappini, Daniele Crocetti, Andrea Polistena, Luigi Petramala, Simone Sibio, Giorgio De Toma, Enrico Fiori, Claudio Letizia

Abstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Contemporary Approaches to Adrenocortical Carcinoma.Hematology/oncology clinics of North America · 2026
    Review
  3. Article
  4. Article
  5. Clinicopathological characteristics of adrenocortical carcinoma in the Kyushu-Okinawa area of Japan.International journal of urology : official journal of the Japanese Urological Association · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giuseppe CavallaroDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-7121-2295
Mariarita TaralloDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-3783-4749
Ambra ChiappiniDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-2792-3548
Daniele CrocettiDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-9950-3553
Andrea PolistenaDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.
Luigi PetramalaDepartment of Translational and Precision Medicine, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-4463-4956
Simone SibioDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.
Giorgio De TomaDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.
Enrico FioriDepartment of Surgery "Pietro Valdoni", Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-5171-6127
Claudio LetiziaDepartment of Translational and Precision Medicine, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-4397-0624

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdrenocortical carcinoma (ACC) is a rare tumor, often discovered at an advanced stage and associated with poor prognosis. Treatment is guided by staging according to the European Network for the Study of Adrenal Tumors (ENSAT) classification. Surgery is the treatment of choice for ACC. The aim of this review is to provide a complete overview on surgical approaches and management of adrenocortical carcinoma.

methodsThis comprehensive review has been carried out according to the PRISMA statement. The literature sources were the databases PubMed, Scopus and Cochrane Library. The search thread was: ((surgery) OR (adrenalectomy)) AND (adrenocortical carcinoma).

resultsAmong all studies identified, 17 were selected for the review. All of them were retrospective. A total of 2498 patients were included in the studies, of whom 734 were treated by mini-invasive approaches and 1764 patients were treated by open surgery.

conclusionsSurgery is the treatment of choice for ACC. Open adrenalectomy (OA) is defined as the gold standard. In recent years laparoscopic adrenalectomy (LA) has gained more popularity. No significant differences were reported for overall recurrence rate, time to recurrence, and cancer-specific mortality between LA and OA, in particular for Stage I-II. Robotic adrenalectomy (RA) has several advantages compared to LA, but there is still a lack of specific documentation on RA use in ACC.

Indexed as

adrenocortical carcinomacurrent methods of treatmentlaparoscopic adrenalectomyrobotic adrenalectomy

Identifiers

PMID34440112
PMCPMC8389566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.