Evidence map›Paper›PMID 34440079›Full record

ArticleBiomedicines2021

Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients.

Ema Rastoder, Pradeesh Sivapalan, Josefin Eklöf, Mohamad Isam Saeed, Alexander Svorre Jordan, Howraman Meteran, Louise Tønnesen, Tor Biering-Sørensen, Anders Løkke, Niels Seersholm and 13 more

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Rare Case of Chronic Limb-Threatening Ischemia in a 32-Year-Old Patient with Nephrotic Syndrome: A Case Report.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. The Standardized Prophylaxis and Risk Factors for Venous Thromboembolism in Patients of Respiratory Intensive Care Unit: A Retrospective Observational Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ema RastoderSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Pradeesh SivapalanSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.ORCID 0000-0002-8620-3655
Josefin EklöfSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Mohamad Isam SaeedSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.ORCID 0000-0002-9246-7630
Alexander Svorre JordanSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Howraman MeteranSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Louise TønnesenSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Tor Biering-SørensenSection of Cardiovascular Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Anders LøkkeDepartment of Medicine, Hospital Lillebælt, 7100 Vejle, Denmark.ORCID 0000-0002-6905-4141
Niels SeersholmSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Thyge Lynghøj NielsenSection of Respiratory Medicine and Infectious Disease, Nordsjællands Hospital, 3400 Hillerød, Denmark.
Jørn CarlsenDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Julie JannerSection of Respiratory Medicine, Amager and Hvidovre Hospital, 2650 Hvidovre, Denmark.
Nina GodtfredsenSection of Respiratory Medicine, Amager and Hvidovre Hospital, 2650 Hvidovre, Denmark.
Uffe BodtgerSection of Respiratory Medicine, Næstved Hospital, 4700 Næstved, Denmark.ORCID 0000-0002-1231-9209
Christian B LaursenDepartment of Respiratory Medicine, Odense University Hospital, Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of South Denmark, 5000 Odense, Denmark.
Ole HilbergDepartment of Medicine, Hospital Lillebælt, 7100 Vejle, Denmark.
Filip K KnopCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.ORCID 0000-0002-2495-5034
Helene PrieméSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2730 Herlev, Denmark.
Truls Sylvan IngebrigtsenDepartment of Respiratory Medicine, Roskilde Hospital, 4000 Roskilde, Denmark.
Vibeke GottliebSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Jon Torgny WilckeSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.
Jens Ulrik Stæhr JensenSection of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.ORCID 0000-0003-4036-0521

Funding

Novo Nordisk Fonden NNF20OC0060657
6 · The paper itself

Abstract

Due to frequent exacerbations, many patients with chronic obstructive pulmonary disease (COPD) are exposed to oral corticosteroids (OCS), which may be thrombogenic. We evaluated the risk of hospitalisation with venous thromboembolism (VTE) and death in patients with acute exacerbation of COPD (AECOPD) treated with long and short OCS regimens. In this nationwide cohort study of 30,473 COPD outpatients treated for AECOPD, we compared the risk of VTE hospitalisation and all-cause mortality within 6 months in OCS dose of >250 mg vs. ≤250 mg. A multivariable Cox proportional hazard regression was used to estimate the risk. The incidence of VTE hospitalisations was 0.23%. A long OCS treatment course was associated with an increased risk of VTE compared to a short course (hazard ratio (HR) 1.69, [95% confidence interval (CI) 1.05 to 2.72],

Indexed as

COPDcorticosteroidsexacerbationpulmonary embolismvenous thromboembolism

Identifiers

PMID34440079
PMCPMC8389624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.