ReviewBiomedicines2021
Platelet-Therapeutics to Improve Tissue Regeneration and Wound Healing-Physiological Background and Methods of Preparation.
Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Innovative strategies on accelerating skin wound healing in dogs using chitosan-coated zinc oxide nanoparticles delivered by two different routes.Journal of veterinary research · 2026Article
- Advances in Living Cell-Mediated Nanodrug Delivery Systems: Construction Strategies, Applications and Challenges.Pharmaceutics · 2026Review
- Platelet Concentrates in Periodontal Regeneration: A Review of Current Evidence and Clinical Perspectives.Cureus · 2026Review
- Culture medium influences detectability of antimicrobial effects of autologous platelet concentrates against anaerobic periodontal pathogens.BMC oral health · 2026Article
- Antibacterial Activity of Fresh and Autoclaved Platelet-Rich Fibrin on Pseudomonas aeruginosa: An In Vitro Study.Journal of clinical laboratory analysis · 2026Article
- In Vitro Antimicrobial Potential of Different Platelet Concentrates Against Eight Clinically Relevant Oral Pathobionts.Antibiotics (Basel, Switzerland) · 2026Article
- Two cases of severe incision infection after cesarean section: a case report.Frontiers in medicine · 2026Article
- Blood derivatives as monotherapy and combination therapy: A promising strategy for wound healing.Regenerative therapy · 2025Review
- Article
- Activated Growth Factor (AGF) as a Superior Biological Therapy for Osteoarthritis: Comparative Efficacy in Modulating Cartilage Degeneration and Inflammation in vivo.Biologics : targets & therapy · 2025Article
- Comparative analysis of cytokine profiles in canine injectable platelet-rich fibrin and platelet-rich plasma.International journal of veterinary science and medicine · 2025Article
- Activated Growth Factor From Platelets as Treatment for Diabetic Retinopathy Through Antioxidant-Oxidative Stress Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Platelet-rich fibrin in the management of oral mucosal lesions: a scoping review.BMC oral health · 2024Article
- Beyond Blood Clotting: The Many Roles of Platelet-Derived Extracellular Vesicles.Biomedicines · 2024Review
- Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration.Life (Basel, Switzerland) · 2023Review
- Supernatant of activated platelet-rich plasma rejuvenated aging-induced hyposalivation in mouse.Scientific reports · 2023Article
- Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis.Clinical immunology (Orlando, Fla.) · 2023Article
- Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing.Journal of diabetes research · 2023Article
- Autologous platelet-rich fibrin promotes wound healing in cats.Frontiers in veterinary science · 2023Article
- [Research advances on the treatment of diabetic foot ulcers with autologous platelet-rich fibrin].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides their function in primary hemostasis, platelets are critically involved in the physiological steps leading to wound healing and tissue repair. For this purpose, platelets have a complex set of receptors allowing the recognition, binding, and manipulation of extracellular structures and the detection of pathogens and tissue damage. Intracellular vesicles contain a huge set of mediators that can be released to the extracellular space to coordinate the action of platelets as other cell types for tissue repair. Therapeutically, the most frequent use of platelets is the intravenous application of platelet concentrates in case of thrombocytopenia or thrombocytopathy. However, there is increasing evidence that the local application of platelet-rich concentrates and platelet-rich fibrin can improve wound healing and tissue repair in various settings in medicine and dentistry. For the therapeutic use of platelets in wound healing, several preparations are available in clinical practice. In the present study we discuss the physiology and the cellular mechanisms of platelets in hemostasis and wound repair, the methods used for the preparation of platelet-rich concentrates and platelet-rich fibrin, and highlight some examples of the therapeutic use in medicine and dentistry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.