ReviewBiomedicines2021
Post-Operative Adhesions: A Comprehensive Review of Mechanisms.
Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Common auricular acupoint patterns for postoperative recovery across laparoscopic surgeries: a data mining-based systematic analysis.Frontiers in medicine · 2026Pooled it
- Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review.Clinical anatomy (New York, N.Y.) · 2026Review
- Bioinspired Injectable Thermosensitive Gallic Acid-Conjugated Hyaluronic Acid/Pluronic Hydrogels to Prevent Postoperative Adhesion.Biomimetics (Basel, Switzerland) · 2026Article
- Classifying the structural heterogeneity of peritoneal adhesions by histopathological extracellular matrix characteristics.Langenbeck's archives of surgery · 2026Article
- Pathophysiology, prevention and treatment of postoperative peritoneal adhesions: a WSES narrative.World journal of emergency surgery : WJES · 2026Review
- Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.The Journal of clinical investigation · 2026Article
- Effects of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film on Postoperative Pain and Peritoneal Adhesion in a Rat Model.Medicina (Kaunas, Lithuania) · 2026Article
- Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.Drug delivery and translational research · 2026Article
- Ultrasound-guided hydrorelease/hydrodissection reduces gliding resistance in a rat sciatic nerve adhesion model : a preclinical experimental study.Journal of orthopaedic surgery and research · 2026Article
- Lack of Antenatal Care Resulting in Intraoperative Diagnostic Challenges of Dense Adhesions Imitating Placenta Accreta Spectrum: A Case Report.International medical case reports journal · 2026Article
- Dynamic perioperative inflammatory biomarkers predict intrauterine adhesion formation following hysteroscopic myomectomy: a prospective cohort study.Frontiers in medicine · 2026Article
- Evaluation of a Sprayable Hydrogel for Surgical Adhesion Prevention in Rat and Rabbit Models.Medical devices (Auckland, N.Z.) · 2026Article
- Sacubitril/Valsartan: Breaking barriers in uterine adhesion and boosting pregnancy outcomes by suppressing inflammation and fibrosis.Iranian journal of basic medical sciences · 2026Article
- Treatment withCurrent pharmaceutical design · 2026Article
- Comparison of outcomes between laparotomic and laparoscopic elective ovariectomy in anestrus dogs: postoperative recovery, pain and inflammatory biomarkers.Veterinary research communications · 2025Article
- Study of the effect of zinc oxide nanoparticles coated with salicylic acid on intra-abdominal adhesions in rats.BMC gastroenterology · 2025Article
- Engineering ROS-responsive double network hydrogel as bioactive barrier for postoperative abdominal adhesions prevention.Bioactive materials · 2025Article
- Fatal small bowel perforation complicating intestinal obstruction in pregnancy: A case report.World journal of clinical cases · 2025Article
- Single-Step Engineered Gelatin-Based Hydrogel for Integrated Prevention of Postoperative Adhesion and Promotion of Wound Healing.Gels (Basel, Switzerland) · 2025Article
- Molecular and Cellular Mechanisms of Fibrosis of Abdominal Adhesions under the Influence of Oxidized Dextran in the Experiment.Bulletin of experimental biology and medicine · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-surgical adhesions are common in almost all surgical areas and are associated with significant rates of morbidity, mortality, and increased healthcare costs, especially when a patient requires repeat operative interventions. Many groups have studied the mechanisms driving post-surgical adhesion formation. Despite continued advancements, we are yet to identify a prevailing mechanism. It is highly likely that post-operative adhesions have a multifactorial etiology. This complex pathophysiology, coupled with our incomplete understanding of the underlying pathways, has resulted in therapeutic options that have failed to demonstrate safety and efficacy on a consistent basis. The translation of findings from basic and preclinical research into robust clinical trials has also remained elusive. Herein, we present and contextualize the latest findings surrounding mechanisms that have been implicated in post-surgical adhesion formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.