Evidence map›Paper›PMID 34439984›Full record

ArticleBiology2021

Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers.

Miloslav Klugar, Abanoub Riad, Mohamed Mekhemar, Jonas Conrad, Mayte Buchbender, Hans-Peter Howaldt, Sameh Attia

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 8 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 8 syntheses or guidelines pooled it, 234 citations in OpenAlex.

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  18. Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Miloslav KlugarCzech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.ORCID 0000-0002-2804-7295
Abanoub RiadCzech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.ORCID 0000-0001-5918-8966
Mohamed MekhemarClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Kiel University, Arnold Heller Str. 3, Haus B, 24105 Kiel, Germany.ORCID 0000-0003-4294-757X
Jonas ConradClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Kiel University, Arnold Heller Str. 3, Haus B, 24105 Kiel, Germany.
Mayte BuchbenderDepartment of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstraße 11, 91054 Erlangen, Germany.ORCID 0000-0001-8295-9714
Hans-Peter HowaldtDepartment of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
Sameh AttiaDepartment of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.ORCID 0000-0002-9174-6435
Christian-Albrechts-Universität zu Kiel · DEJustus-Liebig-Universität Gießen · DEMasaryk University · CZFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

Masarykova Univerzita MUNI/A/1608/2020Masarykova Univerzita MUNI/IGA/1543/2020Ministerstvo Školství, Mládeže a Tělovýchovy LTC20031
6 · The paper itself

Abstract

backgroundthe increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1-3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%;

Indexed as

adverse effectsBTN162 vaccineChAdOx1 COVID-19 vaccineCOVID-19 vaccinescross-sectional studiesdrug-related side effects and adverse reactionsGermanyhealth personnelmRNA-1273 vaccineprevalence

Identifiers

PMID34439984
PMCPMC8389568
OpenAlexW3188612134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.