Evidence map›Paper›PMID 34439968›Full record

ArticleBiology2021

Association between Inguinal Hernia and Arterial Disease: A Preliminary Report.

Raffaele Serra, Umberto Marcello Bracale, Rosy Conforto, Arturo Roncone, Nicola Ielapi, Ashour Michael, Maurizio Sodo, Maria Donata Di Taranto, Pasquale Mastroroberto, Giuseppe Filiberto Serraino and 2 more

Abstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raffaele SerraInteruniversity Center of Phlebolymphology (CIFL), "Magna Graecia" University of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-4477-7412
Umberto Marcello BracaleDepartment of Public Health, University of Naples "Federico II", 80100 Naples, Italy.ORCID 0000-0001-9507-9791
Rosy ConfortoInteruniversity Center of Phlebolymphology (CIFL), "Magna Graecia" University of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0001-7919-0043
Arturo RonconeDepartment Surgery, Hospital of Soverato, 88068 Soverato, Italy.
Nicola IelapiDepartment of Public Health and Infectious Disease, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1011-9844
Ashour MichaelDepartment of Health Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.
Maurizio SodoDepartment of Public Health, University of Naples "Federico II", 80100 Naples, Italy.
Maria Donata Di TarantoDepartment of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, 80100 Naples, Italy.ORCID 0000-0002-0618-7940
Pasquale MastrorobertoDepartment of Experimental and Clinical Medicine, University of Catanzaro, 88100 Catanzaro, Italy.
Giuseppe Filiberto SerrainoDepartment of Experimental and Clinical Medicine, University of Catanzaro, 88100 Catanzaro, Italy.
Michele ProvenzanoDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-2168-702X
Michele AndreucciDepartment of Health Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInguinal hernia (IH) is a major problem in general surgery and its prevalence is increasing. The presence of hernias has been associated with a wide spectrum of venous diseases, with the involvement of imbalances in collagen and extracellular matrix deposition and metalloproteinases dysfunction. We aimed to evaluate whether the association between IH and vascular diseases is also present with respect to arterial diseases.

methodsWe designed a cross-sectional observational study enrolling consecutive patients undergoing surgical repair of IH. Arterial diseases (AD) considered were carotid stenosis, peripheral artery disease and abdominal aortic aneurysms.

resultsStudy population consisted of 70 patients. Mean age was 63.2 ± 4.7 years. Prevalence of AD was 42.9% in the whole cohort. AD patients were older (

conclusionsPrevalence of AD in patients with IH is non-negligible. Old age, a smoking habit and an abnormal excretion of urine albumin are associated with the presence of AD in these patients. Future studies are needed to gain more insights into the pathogenic mechanisms underlying this association, exploring also the specific role of metalloproteinases.

Indexed as

aneurismarterial diseasecarotidinguinal herniametalloproteinasesperipheral artery diseasevascular

Identifiers

PMID34439968
PMCPMC8389546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.