Evidence map›Paper›PMID 34439951›Full record

ArticleBiology2021

Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in the Ischemic Neurons.

Tae-Kyeong Lee, Dae Won Kim, Jae-Chul Lee, Cheol Woo Park, Hyejin Sim, Ji Hyeon Ahn, Joon Ha Park, Myoung Cheol Shin, Jun Hwi Cho, Choong-Hyun Lee and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tae-Kyeong LeeDepartment of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Dae Won KimDepartment of Biochemistry and Molecular Biology and Research Institute of Oral Sciences, College of Dentistry, Kangnung-Wonju National University, Gangneung 25457, Korea.ORCID 0000-0001-8785-4508
Jae-Chul LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Cheol Woo ParkDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Hyejin SimDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Ji Hyeon AhnDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.
Joon Ha ParkDepartment of Anatomy, College of Korean Medicine, Dongguk University, Gyeongju 38066, Korea.
Myoung Cheol ShinDepartment of Emergency Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon 24289, Korea.
Jun Hwi ChoDepartment of Emergency Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon 24289, Korea.
Choong-Hyun LeeDepartment of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Korea.ORCID 0000-0001-5508-9004
Moo-Ho WonDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.ORCID 0000-0002-7178-6501
Soo Young ChoiDepartment of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.

Funding

National Research Foundation of Korea NRF-2019R1A6A1A11036849National Research Foundation of Korea NRF-2020R1F1A1052380
6 · The paper itself

Abstract

Inadequate activation of cell cycle proteins including cyclin D1 and cdk4 is involved in neuronal cell death induced by diverse pathological stresses, including transient global brain ischemia. The neuroprotective effect of ischemic preconditioning is well-established, but the underlying mechanism is still unknown. In this study, we examined changes in cyclin D1, cdk4, and related molecules in cells or neurons located in Cornu Ammonis 1 (CA1) of gerbil hippocampus after transient ischemia for 5 min (ischemia and reperfusion) and investigated the effects of IPC on these molecules after ischemia. Four groups were used in this study as follows: sham group, ischemia group, IPC plus (+) sham group, and IPC+ischemia group. IPC was developed by inducing 2-min ischemia at 24 h before 5-min ischemia (real ischemia). Most pyramidal cells located in CA1 of the ischemia group died five days after ischemia. CA1 pyramidal cells in the IPC+ischemia group were protected. In the ischemia group, the expressions of cyclin D1, cdk4, phosphorylated retinoblastoma (

Indexed as

cyclin D1/cdk4 signalsgerbilhippocampusischemic preconditioningpyramidal cellstransient global ischemia

Identifiers

PMID34439951
PMCPMC8389197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.