Evidence map›Paper›PMID 34439887›Full record

ArticleBiomolecules2021

HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study.

Gerardo Cazzato, Anna Colagrande, Antonietta Cimmino, Gerolamo Cicco, Vincenza Sara Scarcella, Paola Tarantino, Lucia Lospalluti, Paolo Romita, Caterina Foti, Aurora Demarco and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Gerardo CazzatoSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0325-4316
Anna ColagrandeSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Antonietta CimminoSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Gerolamo CiccoSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Vincenza Sara ScarcellaSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Paola TarantinoSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Lucia LospallutiSection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Paolo RomitaSection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Caterina FotiSection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Aurora DemarcoSection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Sara SabloneSection of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-2864-3521
Pragnell Maria Victoria CandanceSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Sebastiano CiccoSection of Internal Medicine "G. Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70124 Bari, Italy.ORCID 0000-0002-1980-5728
Teresa LettiniSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0860-3044
Giuseppe IngravalloSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-4792-3545
Leonardo RestaSection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-4335-4776
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has completely disrupted the health systems of the entire planet. From the earliest months, it became increasingly clear that in addition to affecting the upper airways and lungs, there were other organs that could be affected. Among these, the skin became a real "sentinel signal" to be able to even suspect COVID-19.

Indexed as

AdultAgedCOVID-19FemaleHeme Oxygenase (Decyclizing)Hepatitis A Virus Cellular Receptor 2HMGB1 ProteinHumansMaleMiddle AgedSkinSkin DiseasesT-LymphocytesHAVCR2 protein, humanHeme Oxygenase (Decyclizing)Hepatitis A Virus Cellular Receptor 2HMGB1 ProteinHMGB1 protein, humanHMGB1HO-1SARS-CoV-2skinTIM-3

Identifiers

PMID34439887
PMCPMC8392002
OpenAlexW3193439971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.