Evidence map›Paper›PMID 34439864›Full record

ArticleBiomolecules2021

C-KIT Expression in Orbital Cavernous Venous Hemangiomas.

Mizhir Atallah, Natalia Edison, Esther Levi, Irit Elmalah, Daniel Briscoe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Biological identity of orbital cavernous venous malformations.Arquivos brasileiros de oftalmologia · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mizhir AtallahOphthalmology Department, Emek Medical Center, Afula 18101, Israel.
Natalia EdisonThe Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel.
Esther LeviLaboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel.
Irit ElmalahThe Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel.
Daniel BriscoeOphthalmology Department, Emek Medical Center, Afula 18101, Israel.
Emek Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orbital (slow flow) cavernous venous hemangiomas (OCVH) are the most common benign orbital tumors in adults. The c-KIT is a tyrosine kinase receptor, which is expressed on several types of cells, is thought to play a key role in tumor pathogenesis. The purpose of this study was to evaluate the presence of the receptor c-KIT in OCVH. Our retrospective study examined 16 orbital cavernous venous hemangiomas from 16 cases operated on between 2006-2016 at Emek Medical Center. The mean tumor size was 18.4 mm. Symptoms appeared between 6 months and 22 years before operation. All specimens were analyzed for the c-KIT receptor through immunohistochemistry. The c-KIT was expressed by the endothelium in all 16 preparates. Staining was strong in two cases, moderate in six, and weak in eight cases, with no statistically significant correlation between staining and tumor size (

Indexed as

Gene Expression Regulation, NeoplasticAdolescentAdultAgedChildFemaleHemangioma, CavernousHumansMaleMiddle AgedOrbital NeoplasmsProto-Oncogene Proteins c-kitYoung AdultKIT protein, humanProto-Oncogene Proteins c-kitc-KITimmunohistochemistryorbital cavernous hemangioma

Identifiers

PMID34439864
PMCPMC8392613
OpenAlexW3189316318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.