Evidence map›Paper›PMID 34439847›Full record

ArticleBiomolecules2021

Grape Pomace for Topical Application: Green NaDES Sustainable Extraction, Skin Permeation Studies, Antioxidant and Anti-Inflammatory Activities Characterization in 3D Human Keratinocytes.

Angela Punzo, Emanuele Porru, Alessia Silla, Patrizia Simoni, Paola Galletti, Aldo Roda, Emilio Tagliavini, Chiara Samorì, Cristiana Caliceti

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025
    Review
  11. Review
  12. Recent Trends in Nanoantioxidants.Antioxidants (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Exploring Phenolic Compounds in Crop By-Products for Cosmetic Efficacy.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Angela PunzoDepartment of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Emanuele PorruDepartment of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Alessia SillaDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Patrizia SimoniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
Paola GallettiDepartment of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Aldo RodaDepartment of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-7649-4797
Emilio TagliaviniDepartment of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Chiara SamorìDepartment of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Cristiana CalicetiDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-6740-5331
University of Bologna · ITIstituto Nazionale Biostrutture e Biosistemi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food waste is a global problem due to its environmental and economic impact, so there is great demand for the exploitation of new functional applications. The winemaking process leads to an incomplete extraction of high-value compounds, leaving the pomace still rich in polyphenols. This study was aimed at optimising and validating sustainable routes toward the extraction and further valorisation of these polyphenols, particularly for cosmeceutical applications. New formulations based on red grape pomace polyphenols and natural deep eutectic solvents (NaDESs) were here investigated, namely betaine combined with citric acid (BET-CA), urea (BET-U) and ethylene glycol (BET-EG), in which DESs were used both as extracting and carrying agents for polyphenols. The flavonoid profile determined by HPLC-MS/MS analysis showed similar malvidin content (51-56 μg mL

Indexed as

Anti-Inflammatory AgentsAntioxidantsCosmeticsHaCaT CellsHumansOxidative StressPlant ExtractsPolyphenolsRefuse DisposalVitisAnti-Inflammatory AgentsAntioxidantsCosmeticsPlant ExtractsPolyphenolshuman 3D keratinocytesinflammationmalvidinnatural deep eutectic solvents (NaDES)oxidative stressred grape pomace skinskin permeation

Identifiers

PMID34439847
PMCPMC8393215
OpenAlexW3191298339

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.