Evidence map›Paper›PMID 34439815›Full record

Observational studyBiomolecules2021

Serum Chemerin Concentration Is Associated with Proinflammatory Status in Chronic Coronary Syndrome.

Anna Szpakowicz, Malgorzata Szpakowicz, Magda Lapinska, Marlena Paniczko, Slawomir Lawicki, Andrzej Raczkowski, Marcin Kondraciuk, Emilia Sawicka, Malgorzata Chlabicz, Marcin Kozuch and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. A Slow Hydrogen Sulfide Donor GYY-4137 Partially Improves Vascular Function in Spontaneously Hypertensive Rats Fed a High-Fat Diet.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anna SzpakowiczDepartment of Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Malgorzata SzpakowiczDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Magda LapinskaDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Marlena PaniczkoDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Slawomir LawickiDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.ORCID 0000-0001-6747-2123
Andrzej RaczkowskiDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.ORCID 0000-0002-7410-2136
Marcin KondraciukDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Emilia SawickaDepartment of Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Malgorzata ChlabiczDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Marcin KozuchDepartment of Invasive Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Maciej PoludniewskiDepartment of Invasive Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Slawomir DobrzyckiDepartment of Invasive Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Irina KowalskaDepartment of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.
Karol KaminskiDepartment of Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemerin is an adipokine and a chemoattractant for leukocytes. Increased chemerin levels were observed in patients with coronary artery disease (CAD). We investigated associations between chemerin and biochemical measurements or body composition in CAD patients.

methodsIn the study, we included patients with stable CAD who had undergone percutaneous coronary intervention (PCI) in the past. All patients had routine blood tests, and their insulin and chemerin serum levels were routinely measured. Body composition was assessed with the DEXA method.

resultsThe study group comprised 163 patients (mean age 59.8 ± years, 26% of females, n = 43). There was no significant difference in serum chemerin concentrations between patients with diabetes and the remaining ones: 306.8 ± 121 vs. 274.15 ± 109 pg/mL,

conclusionIn patients with CAD, serum chemerin levels are correlated with inflammation markers, insulin resistance, and an unfavorable lipid profile. Correlation with fat mass is dependent on glucose metabolism status. Depending on the presence of diabetes/prediabetes, the mechanisms regulating chemerin secretion may be different.

Indexed as

AgedBlood GlucoseBlood PlateletsBody CompositionChemokinesCholesterol, HDLCholesterol, LDLCoronary Artery DiseaseC-PeptideC-Reactive ProteinDiabetes Mellitus, Type 2FemaleHumansInflammationInsulinInsulin ResistanceBlood GlucoseChemokinesCholesterol, HDLCholesterol, LDLC-PeptideC-Reactive ProteinInsulinRARRES2 protein, humanTriglyceridesbody compositionchemerincoronary artery diseaseinsulin resistanceneutrophil to lymphocyte ratiowhite blood cells count

Identifiers

PMID34439815
PMCPMC8392272

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.