Evidence map›Paper›PMID 34439814›Full record

ArticleBiomolecules2021

Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells.

Trevor Teafatiller, Sudhanshu Agrawal, Gabriela De Robles, Farah Rahmatpanah, Veedamali S Subramanian, Anshu Agrawal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  9. Ascorbate Is a Primary Antioxidant in Mammals.Molecules (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Trevor TeafatillerDivision of Gastroenterology, Department of Medicine, University of California, Irvine, CA 92697, USA.
Sudhanshu AgrawalDivision of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA.
Gabriela De RoblesDepartment of Pathology, University of California, Irvine, CA 92697, USA.
Farah RahmatpanahDepartment of Pathology, University of California, Irvine, CA 92697, USA.
Veedamali S SubramanianDivision of Gastroenterology, Department of Medicine, University of California, Irvine, CA 92697, USA.
Anshu AgrawalDivision of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-3323-9152
University of California, Irvine · US

Funding

NIH HHS DK107474
6 · The paper itself

Abstract

Vitamin C is well documented to have antiviral functions; however, there is limited information about its effect on airway epithelial cells-the first cells to encounter infections. Here, we examined the effect of vitamin C on human bronchial epithelium transformed with Ad12-SV40 2B (BEAS-2B) cells, and observed that sodium-dependent vitamin C transporter 2 (SVCT2) was the primary vitamin C transporter. Transcriptomic analysis revealed that treating BEAS-2B cells with vitamin C led to a significant upregulation of several metabolic pathways and interferon-stimulated genes (ISGs) along with a downregulation of pathways involved in lung injury and inflammation. Remarkably, vitamin C also enhanced the expression of the viral-sensing receptors retinoic acid-inducible gene 1 (RIG-1) and melanoma differentiation-associated protein 5 (MDA-5), which was confirmed at the protein and functional levels. In addition, the lungs of l-gulono-γ-lactone oxidase knockout (

Indexed as

AnimalsAntiviral AgentsAscorbic AcidBiological TransportBronchiCell Line, TransformedDEAD Box Protein 58Epithelial CellsGene Expression RegulationHumansInterferon-alphaInterferon-Induced Helicase, IFIH1Interferon Regulatory FactorsInterleukin-6Interleukin-8L-Gulonolactone OxidaseAntiviral AgentsAscorbic AcidCXCL8 protein, humanDEAD Box Protein 58IFIH1 protein, humanIL6 protein, humanInterferon-alphaInterferon-Induced Helicase, IFIH1Interferon Regulatory FactorsInterleukin-6Interleukin-8L-Gulonolactone OxidaseMX1 protein, humanMyxovirus Resistance ProteinsPLAAT4 protein, humanPoly I-CReceptors, ImmunologicReceptors, Retinoic AcidRIGI protein, humanSLC23A2 protein, humanSodium-Coupled Vitamin C Transportersairway epithelial cellsantiviral responsesGULO-KO miceISGsvitamin Cvitamin C transporters

Identifiers

PMID34439814
PMCPMC8394979
OpenAlexW3189020964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.