Evidence map›Paper›PMID 34439812›Full record

ArticleBiomolecules2021

High Mobility Group Box 1 in Pig Amniotic Membrane Experimentally Infected with

Igor Splichal, Alla Splichalova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Igor SplichalLaboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.ORCID 0000-0003-3665-1377
Alla SplichalovaLaboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.ORCID 0000-0002-7428-7687
Czech Academy of Sciences, Institute of Microbiology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intra-amniotic infections (IAI) are one of the reasons for preterm birth. High mobility group box 1 (HMGB1) is a nuclear protein with various physiological functions, including tissue healing. Its excessive extracellular release potentiates inflammatory reaction and can revert its action from beneficial to detrimental. We infected the amniotic fluid of a pig on the 80th day of gestation with 1 × 10

Indexed as

AmnionAmniotic FluidAnimalsDisease Models, AnimalEscherichia coliEscherichia coli InfectionsFemaleGene Expression RegulationHMGB1 ProteinHost-Pathogen InteractionsHumansPregnancyPregnancy Complications, InfectiousPremature BirthReceptor for Advanced Glycation End ProductsRNA, MessengerHMGB1 ProteinReceptor for Advanced Glycation End ProductsRNA, MessengerToll-Like Receptor 4amniotic fluidamniotic membranecytokineshigh mobility group box 1intra-amniotic infectionpigpreterm birthreceptor for advanced glycation endproductsToll-like receptor

Identifiers

PMID34439812
PMCPMC8393629
OpenAlexW3188394704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.