Evidence map›Paper›PMID 34439801›Full record

ArticleBiomolecules2021

Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.

Rosa Maria Vitale, Fabio Arturo Iannotti, Aniello Schiano Moriello, Lea Tunisi, Fabiana Piscitelli, Ranjev Savopoulos, Luigia Cristino, Luciano De Petrocellis, Pietro Amodeo, Roy Gray and 1 more

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Antagonization of OXInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Rosa Maria VitaleInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0001-9243-1307
Fabio Arturo IannottiInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0003-4480-8370
Aniello Schiano MorielloEndocannabinoid Research Group (ERG), Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Lea TunisiEndocannabinoid Research Group (ERG), Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Fabiana PiscitelliInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Ranjev SavopoulosGW Research Ltd., Sovereign House, Vision Park, Histon, Cambridge CB24 9BZ, UK.
Luigia CristinoInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Luciano De PetrocellisInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0002-6131-0470
Pietro AmodeoInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0002-6439-7575
Roy GrayGW Research Ltd., Sovereign House, Vision Park, Histon, Cambridge CB24 9BZ, UK.
Vincenzo Di MarzoInstitute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Istituto di Chimica Biomolecolare · ITGW Pharmaceuticals (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential, multifaceted therapeutic profile of cannabidiol (CBD), a major constituent derived from the

Indexed as

AnimalsAnti-Anxiety AgentsAnticonvulsantsBinding SitesCalciumCannabidiolCHO CellsCricetulusGene ExpressionHumansKineticsMolecular Docking SimulationMolecular ImagingOrexin Receptor AntagonistsOrexin ReceptorsOrexinsAnti-Anxiety AgentsAnticonvulsantsCalciumCannabidiolHCRTR1 protein, humanHCRTR2 protein, humanOrexin Receptor AntagonistsOrexin ReceptorsOrexinscalcium mobilization assaycannabidiolmolecular dockingmolecular dynamicsorexin receptors

Identifiers

PMID34439801
PMCPMC8394412
OpenAlexW3189812176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.