Evidence map›Paper›PMID 34439797›Full record

ReviewBiomolecules2021

Transportation of Single-Domain Antibodies through the Blood-Brain Barrier.

Eduardo Ruiz-López, Alberto J Schuhmacher

Abstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Review
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  18. Current Trends in Clinical Trials of Prodrugs.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eduardo Ruiz-LópezMolecular Oncology Group, Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain.ORCID 0000-0002-1023-5650
Alberto J SchuhmacherMolecular Oncology Group, Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain.ORCID 0000-0002-0136-1049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-domain antibodies derive from the heavy-chain-only antibodies of

Indexed as

TranscytosisAnimalsBlood-Brain BarrierBrainCamelidaeCell-Penetrating PeptidesDrug CarriersExtracellular VesiclesHumansLiposomesModels, MolecularNanoparticlesNeurodegenerative DiseasesPermeabilityProtein ConformationSingle-Domain AntibodiesCell-Penetrating PeptidesDrug CarriersLiposomesSingle-Domain Antibodiesblood–brain barriercarrierscell-penetrating peptidesnanobodynanoparticlessingle-domain antibodiestranscytosisVNAR

Identifiers

PMID34439797
PMCPMC8394617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.