Evidence map›Paper›PMID 34439786›Full record

ReviewBiomolecules2021

Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer.

Olalekan Olanrewaju Bakare, Arun Gokul, Ruomou Wu, Lee-Ann Niekerk, Ashwil Klein, Marshall Keyster

Abstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Peptide Fractions Extracted from the Hemolymph ofInternational journal of molecular sciences · 2025
    Article
  10. Biological Activity of Peptide Fraction Derived fromInternational journal of molecular sciences · 2025
    Article
  11. Review
  12. Review
  13. Modeling the Binding of Anticancer Peptides and Mcl-1.International journal of molecular sciences · 2024
    Article
  14. Application Value of Antimicrobial Peptides in Gastrointestinal Tumors.International journal of molecular sciences · 2023
    Review
  15. Antimicrobial peptides as potential therapy for gastrointestinal cancers.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olalekan Olanrewaju BakareEnvironmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-5856-8286
Arun GokulDepartment of Plant Sciences, Qwaqwa Campus, University of the Free State, Phuthaditjhaba 9866, South Africa.ORCID 0000-0003-1575-0632
Ruomou WuEnvironmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.
Lee-Ann NiekerkEnvironmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-9788-3131
Ashwil KleinPlant Omics Laboratory, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-5606-886X
Marshall KeysterEnvironmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-8718-736X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as therapeutic and diagnostic candidates due to several compensatory advantages over the non-specificity of the current treatment regimens. This review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use. This would create awareness for identifying more ACPs with better specificity, accuracy and sensitivity towards the disease. It would also promote their efficacious utilization in biotechnology, medical sciences and molecular biology to ease the severity of the disease and enable the patients living with these conditions to develop an accommodating lifestyle.

Indexed as

Amino Acid SequenceAntimicrobial Cationic PeptidesAntineoplastic AgentsCell Line, TumorCell MembraneDrug DiscoveryHumansMolecular Targeted TherapyNeoplasmsAntimicrobial Cationic PeptidesAntineoplastic Agentsanticancer peptidesapoptosiscancercytolysishost-defense peptidespeptide delivery

Identifiers

PMID34439786
PMCPMC8394746

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.