Evidence map›Paper›PMID 34439764›Full record

ReviewBiomolecules2021

Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia.

Joanna M Wierońska, Paulina Cieślik, Leszek Kalinowski

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
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  4. Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joanna M WierońskaMaj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Kraków, Poland.
Paulina CieślikMaj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Kraków, Poland.ORCID 0000-0003-1182-573X
Leszek KalinowskiDepartment of Medical Laboratory Diagnostics-Biobank Fahrenheit BBMRI.pl, Medical University of Gdansk, Debinki Street 7, 80-211 Gdansk, Poland.
Maj Institute of Pharmacology · PLGdańsk University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide (NO

Indexed as

AnimalsApoptosisBrain IschemiaDisease ProgressionFree Radical ScavengersHumansHypoxia, BrainHypoxia-Inducible Factor 1, alpha SubunitInflammationIschemiaLymphocytesNecrosisNeuronsNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIFree Radical ScavengersHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINOS2 protein, humanReactive Nitrogen SpeciesReactive Oxygen Speciescerebral ischemiaeNOSexcitotoxicityHIF-1αiNOSnitric oxidenNOSoxidative/nitrosative stress

Identifiers

PMID34439764
PMCPMC8392725
OpenAlexW3185088172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.