Evidence map›Paper›PMID 34439760›Full record

ArticleBiomolecules2021

Neurotransmitter Profiles Are Altered in the Gut and Brain of Mice Mono-Associated with

Berkley Luck, Thomas D Horvath, Kristen A Engevik, Wenly Ruan, Sigmund J Haidacher, Kathleen M Hoch, Numan Oezguen, Jennifer K Spinler, Anthony M Haag, James Versalovic and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 58 citations in OpenAlex.

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  18. Gut sulfide metabolism modulates behavior and brain bioenergetics.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Berkley LuckDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Thomas D HorvathDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9761-3484
Kristen A EngevikDepartment of Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9807-1875
Wenly RuanDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Sigmund J HaidacherDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Kathleen M HochDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Numan OezguenDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3175-2382
Jennifer K SpinlerDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7830-7665
Anthony M HaagDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
James VersalovicDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Melinda A EngevikDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9742-9932
Baylor College of Medicine · USMedical University of South Carolina · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2020 to 2026
$18.7M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612k
NIDDK NIH HHS K01 DK123195NIDDK NIH HHS K01K12319501NIDDK NIH HHS P30 DK123704NIDDK NIH HHS P30-DK-56338NIGMS NIH HHS P20 GM130457
6 · The paper itself

Abstract

backgroundAccumulating evidence indicates that the gut microbiota can synthesize neurotransmitters as well as impact host-derived neurotransmitter levels. In the past, it has been challenging to decipher which microbes influence neurotransmitters due to the complexity of the gut microbiota.

methodsTo address whether a single microbe,

resultsWe found that

conclusionsThese data indicate that

Indexed as

AnimalsBifidobacteriales InfectionsBifidobacteriumBrainCalibrationChromatography, LiquidGastrointestinal MicrobiomeGenomeIntestinesMaleMiceMicrobiotaNeurotransmitter AgentsTandem Mass SpectrometryTyrosineNeurotransmitter AgentsTyrosineBifidobacteriaGABAgut–brain axisgut microbiomeLC-MS/MSneurotransmitters

Identifiers

PMID34439760
PMCPMC8392031
OpenAlexW3183954626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.