Evidence map›Paper›PMID 34439754›Full record

ArticleBiomolecules2021

Shirong Wang, Qiang Cao, Xin Cui, Jia Jing, Fenfen Li, Huidong Shi, Bingzhong Xue, Hang Shi

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Epigenetic Regulation of Hepatic Lipid Metabolism by DNA Methylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  10. Article
  11. AdipocyteCells · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shirong WangDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Qiang CaoDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Xin CuiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Jia JingDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Fenfen LiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Huidong ShiGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-1137-3390
Bingzhong XueDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Hang ShiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Georgia State University · US

Funding

Crosstalk between sensory ghrelin signaling and adipose tissue sympathetic outflow regulates metabolic homeostasisR01DK125081 · NIDDK · GEORGIA STATE UNIVERSITY · PI XUE, BINGZHONG · 2020 to 2023
$2.3M
Epigenetic regulation of brown fat thermogenesis by the histone demethylase KDM6AR01DK118106 · NIDDK · GEORGIA STATE UNIVERSITY · PI SHI, HANG, XUE, BINGZHONG · 2019 to 2022
$1.7M
HDAC1 regulates thermogenic program via H3K27 deacetylationR01DK115740 · NIDDK · GEORGIA STATE UNIVERSITY · PI SHI, HANG · 2018 to 2021
$1.5M
Histone methyltransferase SUV420H2 regulates brown/beige adipocyte thermogenesis and energy homeostasisR01DK107544 · NIDDK · GEORGIA STATE UNIVERSITY · PI XUE, BINGZHONG · 2016 to 2019
$1.4M
NIDDK NIH HHS R01 DK107544NIDDK NIH HHS R01DK107544NIDDK NIH HHS R01 DK115740NIDDK NIH HHS R01DK115740NIDDK NIH HHS R01 DK118106NIDDK NIH HHS R01DK118106NIDDK NIH HHS R01 DK125081NIDDK NIH HHS R01DK125081
6 · The paper itself

Abstract

Increasing energy expenditure through activation of brown fat thermogenesis is a promising therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key player in regulating brown fat development and thermogenic program. Here, we aimed to study the role of DNA methyltransferase 3b (Dnmt3b), a DNA methyltransferase involved in de novo DNA methylation, in the regulation of brown fat function and energy homeostasis. We generated a genetic model with

Indexed as

Adipocytes, BrownAdipose Tissue, BrownAdipose Tissue, WhiteAllelesAnimalsBody WeightCrosses, GeneticDisease Models, AnimalDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BEnergy MetabolismEpigenesis, GeneticFemaleInsulin ResistanceMiceMice, KnockoutDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BMyf5 protein, mouseMyogenic Regulatory Factor 5brown adipocytesDnmt3bepigeneticsobesitythermogenesis

Identifiers

PMID34439754
PMCPMC8393658
OpenAlexW3184056423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.