Evidence map›Paper›PMID 34439745›Full record

ArticleBiomolecules2021

Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation.

JanWillem Duitman, Leonie Hartl, Joris J T H Roelofs, Maarten F Bijlsma, C Arnold Spek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
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  4. Article
  5. The roles of KLHL family members in human cancers.American journal of cancer research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

JanWillem DuitmanLaboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, 1012 VT Amsterdam, The Netherlands.ORCID 0000-0003-4254-3380
Leonie HartlLaboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, 1012 VT Amsterdam, The Netherlands.ORCID 0000-0001-7285-2155
Joris J T H RoelofsDepartment of Pathology, Amsterdam UMC, University of Amsterdam, 1012 VT Amsterdam, The Netherlands.ORCID 0000-0001-9595-6571
Maarten F BijlsmaLaboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, 1012 VT Amsterdam, The Netherlands.ORCID 0000-0001-6627-3229
C Arnold SpekLaboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, 1012 VT Amsterdam, The Netherlands.ORCID 0000-0002-2149-4068
Amsterdam University Medical Centers · NLOncode Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells. Loss of nuclear C/EBPδ in PDAC cells is associated with decreased patient survival and pro-tumorigenic properties in vitro. Interestingly however, next to C/EBPδ expression in tumor cells, C/EBPδ is also expressed by cells constituting the tumor microenvironment and by cells comprising the organs and parenchyma. However, the functional relevance of systemic C/EBPδ in carcinogenesis remains elusive. Here, we consequently assessed the potential importance of C/EBPδ in somatic tissues by utilizing an orthotopic pancreatic cancer model. In doing so, we show that genetic ablation of C/EBPδ does not significantly affect primary tumor growth but has a strong impact on metastases; wildtype mice developed metastases at multiple sites, whilst this was not the case in C/EBPδ

Indexed as

Neoplasm MetastasisAnimalsApoptosisCCAAT-Enhancer-Binding Protein-deltaCell Line, TumorCell ProliferationData MiningDisease ProgressionDNA-Binding ProteinsGene Expression RegulationHumansMiceNeoplasm TransplantationPancreatic NeoplasmsPlatelet Membrane GlycoproteinsReceptors, G-Protein-CoupledCCAAT-Enhancer-Binding Protein-deltaCEBPD protein, humanCebpd protein, ratDNA-Binding Proteinsplatelet activating factor receptorPlatelet Membrane GlycoproteinsReceptors, G-Protein-CoupledTrans-ActivatorsCCAAT/enhancer-binding protein deltaCEBPDextravasationmetastasispancreatic cancerPDAC

Identifiers

PMID34439745
PMCPMC8391339
OpenAlexW3185520143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.