Evidence map›Paper›PMID 34439727›Full record

ArticleBrain sciences2021

Felicia Jennysdotter Olofsgård, Caroline Ran, Carmen Fourier, Catalina Wirth, Christina Sjöstrand, Elisabet Waldenlind, Anna Steinberg, Andrea Carmine Belin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025
    Review
  2. Reviewing the complex relationship between circadian rhythms and cluster headache.Cephalalgia : an international journal of headache · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Felicia Jennysdotter OlofsgårdDepartment of Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.
Caroline RanDepartment of Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0003-0239-9871
Carmen FourierDepartment of Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0001-6618-8948
Catalina WirthDepartment of Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.
Christina SjöstrandDepartment of Clinical Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.
Elisabet WaldenlindDepartment of Clinical Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.
Anna SteinbergDepartment of Clinical Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.
Andrea Carmine BelinDepartment of Neuroscience, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0001-6668-3172

Funding

Hjärnfonden FO2019-0004Hjärnfonden FO2020-0006Karolinska Institutet 2018-01738Karolinska Institutet 2020-00866Vetenskapsrådet 2017-01096
6 · The paper itself

Abstract

The trigeminal autonomic cephalalgia, cluster headache (CH), is one of the most painful disorders known to man. One of the disorder's most striking features is the reported diurnal rhythmicity of the attacks. For a majority of patients, the headache attacks occur at approximately the same time every day. Genetic variants of genes involved in the circadian rhythm such as Period Circadian Regulator 1, 2, and 3 (

Indexed as

clock genesdiurnal preferencediurnal rhythmicitygeneticspain

Identifiers

PMID34439727
PMCPMC8393578

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.