Evidence map›Paper›PMID 34439724›Full record

ArticleBrain sciences2021

Impact of Glucocorticoid on a Cellular Model of Parkinson's Disease: Oxidative Stress and Mitochondrial Function.

Silvia Claros, Antonio Gil, Mauro Martinelli, Nadia Valverde, Estrella Lara, Federica Boraldi, Jose Pavia, Elisa Martín-Montañez, María Garcia-Fernandez

Abstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia ClarosDepartment of Human Physiology, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.
Antonio GilDepartment of Pharmacology and Paediatrics, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.
Mauro MartinelliDepartment of Human Physiology, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.
Nadia ValverdeDepartment of Pharmacology and Paediatrics, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.ORCID 0000-0002-8626-3025
Estrella LaraDepartment of Human Physiology, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.ORCID 0000-0001-7990-064X
Federica BoraldiDepartment of Life Sciences, University of Modena e Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-0277-9017
Jose PaviaDepartment of Pharmacology and Paediatrics, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.ORCID 0000-0002-3121-0735
Elisa Martín-MontañezDepartment of Pharmacology and Paediatrics, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.ORCID 0000-0002-3637-3285
María Garcia-FernandezDepartment of Human Physiology, Faculty of Medicine, Malaga University, Biomedical Research Institute of Malaga, 29010 Malaga, Spain.ORCID 0000-0002-6436-1361

Funding

Proyecto I+D+I Programa Operativo FEDER Andalucía 397 2014-2020 Junta de Andalucía UMA18-FEDERJA- 004
6 · The paper itself

Abstract

Stress seems to contribute to the neuropathology of Parkinson's disease (PD), possibly by dysregulation of the hypothalamic-pituitary-adrenal axis. Oxidative distress and mitochondrial dysfunction are key factors involved in the pathophysiology of PD and neuronal glucocorticoid-induced toxicity. Animal PD models have been generated to study the effects of hormonal stress, but no in vitro model has yet been developed. Our aim was to examine the impact of corticosterone (CORT) administration on a dopaminergic neuronal cell model of PD induced by the neurotoxin MPP

Indexed as

hormonal stressmitochondriaoxidative distressParkinson’s disease

Identifiers

PMID34439724
PMCPMC8391158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.