Evidence map›Paper›PMID 34439700›Full record

ReviewBrain sciences2021

Therapeutic Strategies for Mutant

Neha Mohan, Liang Qiang, Gerardo Morfini, Peter W Baas

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Unraveling Isoform Complexity: The Roles of M1- and M87-Spastin in Spastic Paraplegia 4 (SPG4).Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  4. New Developments in the Surgery for Spasticity.Advances and technical standards in neurosurgery · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Hereditary Spastic Paraplegia: An Update.International journal of molecular sciences · 2022
    Review
  9. The Role of Spastin in Axon Biology.Frontiers in cell and developmental biology · 2022
    Review
  10. A novel variant ofAnnals of translational medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Neha MohanDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19422, USA.
Liang QiangDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19422, USA.
Gerardo MorfiniDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-6059-5518
Peter W BaasDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19422, USA.
Drexel University · USUniversity of Illinois Chicago · US

Funding

MICROTUBULE DYNAMICS AND AXON GROWTHR01NS028785 · NINDS · UNIVERSITY OF WISCONSIN MADISON · PI BAAS, PETER W. · 1990 to 2021
$7.3M
Mechanisms of SPG4 Hereditary Spastic ParaplegiaR01NS118177 · NINDS · DREXEL UNIVERSITY · PI BAAS, PETER W., MORFINI, GERARDO ANDRES · 2020 to 2024
$3.2M
Elucidating the etiology of SPAST-based Hereditary Spastic ParaplegiaR01NS115977 · NINDS · DREXEL UNIVERSITY · PI QIANG, LIANG · 2021 to 2025
$1.8M
Role of Tau in Microtubule Stability in Adult NeuronsR21AG068597 · NIA · DREXEL UNIVERSITY · PI BAAS, PETER W. · 2021 to 2021
$416k
NIA NIH HHS R21 AG068597NINDS NIH HHS R01 NS028785NINDS NIH HHS R01 NS115977NINDS NIH HHS R01 NS118177NINDS NIH HHS R01NS118177
6 · The paper itself

Abstract

Mutations of the

Indexed as

autophagycasein kinase 2gain-of-functiongene therapyhaploinsufficiencyHDAC6Hereditary Spastic Paraplegialoss-of-functionmicrotubuleSPASTspastinSPG4-HSP

Identifiers

PMID34439700
PMCPMC8394973
OpenAlexW3193522152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.