Expression of Microbial Enzymes in Mammalian Astrocytes to Modulate Lactate Release.

Barbara Vaccari Cardoso, Iliana Barrera, Valentina Mosienko, Alexander V Gourine, Sergey Kasparov, Anja G Teschemacher

Open access · goldAbstract read

In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 55% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Learning the metabolic language of cancer.Nature · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Barbara Vaccari CardosoSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

Iliana BarreraSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

Valentina MosienkoInstitute of Biomedical and Clinical Sciences, College of Medicine and Health, University of Exeter, Exeter EX4 4PS, UK.ORCID 0000-0002-8562-532X

Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK.

Sergey KasparovSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

Anja G TeschemacherSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

University of Bristol · GBUniversity College London · GBUniversity of Exeter · GB

Funding

British Heart Foundation PG/18/8/33540British Heart Foundation PG/18/8/33540, RG/19/5/34463Conselho Nacional de Desenvolvimento Científico e Tecnológico 206427/2014-0

6 · The paper itself

Abstract

Astrocytes support and modulate neuronal activity through the release of L-lactate. The suggested roles of astrocytic lactate in the brain encompass an expanding range of vital functions, including central control of respiration and cardiovascular performance, learning, memory, executive behaviour and regulation of mood. Studying the effects of astrocytic lactate requires tools that limit the release of lactate selectively from astrocytes. Here, we report the validation in vitro of novel molecular constructs derived from enzymes originally found in bacteria, that when expressed in astrocytes, interfere with lactate handling. When lactate 2-monooxygenase derived from

Indexed as

astrocytesgliotransmitterlactateviral vectors

Identifiers

PMID34439675

DOI10.3390/brainsci11081056

PMCPMC8394253

OpenAlexW3192730274

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.