Evidence map›Paper›PMID 34439546›Full record

ArticleAntioxidants (Basel, Switzerland)2021

A Novel Immunoassay for Malondialdehyde-Conjugated Low-Density Lipoprotein Measures Dynamic Changes in the Blood of Patients Undergoing Coronary Artery Bypass Graft Surgery.

Samata S Pandey, Adam Hartley, Mikhail Caga-Anan, Tareq Ammari, Ameer Hamid Ahmed Khan, Bao Anh Vu Nguyen, Chiari Kojima, Jon Anderson, Steven Lynham, Michael Johns and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Samata S PandeyVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Adam HartleyVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.ORCID 0000-0003-1431-2200
Mikhail Caga-AnanVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Tareq AmmariVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Ameer Hamid Ahmed KhanVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Bao Anh Vu NguyenVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Chiari KojimaVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Jon AndersonDepartment of Cardiothoracic Surgery, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
Steven LynhamCentre of Excellence for Mass Spectrometry, Proteomics Facility, Denmark Hill Campus, Kings College London, London SE5 9NU, UK.
Michael JohnsVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Dorian O HaskardVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
Ramzi Y KhamisVascular Sciences Section, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.ORCID 0000-0003-4119-5193
Imperial College London · GBImperial College Healthcare NHS Trust · GBKing's College London · GB

Funding

British Heart Foundation FS/17/16/32560Wellcome Trust 095034/Z/10/ZWellcome Trust 220572/Z/20/Z
6 · The paper itself

Abstract

Oxidized low-density lipoproteins play an important role in tissue pathology. In this study, we report a sensitive novel enzyme-linked immunosorbent assay for the detection of malondialdehyde-modified low-density lipoprotein (MDA-LDL), a key component of oxidized LDL. The assay is capable of measuring a variable presence of MDA-LDL within human plasma and serum. We demonstrate the robust nature of the assay on samples stored for over 20 months, as well as high inter-operator reproducibility (r = 0.74,

Indexed as

antibodiesanti-oxidized LDL antibodiesassayatherosclerosisinflammationlow-density lipoprotein (LDL)malondialdehydeoxidized LDL

Identifiers

PMID34439546
PMCPMC8389242
OpenAlexW3193605102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.