ReviewAntioxidants (Basel, Switzerland)2021
Fast Antioxidant Reaction of Polyphenols and Their Metabolites.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Association of dietary oxidative balance score, dietary inflammatory potential and fractures among adults aged ≥ 40 years in the United States in 1999-2018.Asia Pacific journal of clinical nutrition · 2026Article
- Fraction-Dependent Polyphenolic Profile and Biological Activities ofAntioxidants (Basel, Switzerland) · 2026Article
- Reactive MD Screening of Antioxidants for Substituent-Dependent Phenoxyl Radical Stability.ACS omega · 2026Article
- Functional Benefits of Brewer's Spent Grain and the Challenge of Developing Food Ingredients for Human Health.Antioxidants (Basel, Switzerland) · 2026Review
- Polyphenols from Byproducts: Their Applications and Health Effects.Antioxidants (Basel, Switzerland) · 2026Review
- Exploring the potential of polyphenols in major depression: from molecular function to clinical therapy.Frontiers in nutrition · 2026Review
- The impact ofFood chemistry: X · 2026Article
- Assessing biological activities of polyphenols in the context of 4R - challenges of a ubiquitous compound class with complex modes of action.Frontiers in pharmacology · 2026Review
- Antioxidant Potential of Polyphenolic Compounds, Sources, Extraction, Purification and Characterization Techniques: A Focused Review.Food science & nutrition · 2025Review
- A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application.Journal of nanobiotechnology · 2025Review
- Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective.Journal of translational medicine · 2025Article
- The Impact of Plant-Derived Polyphenols on Combating Efflux-Mediated Antibiotic Resistance.International journal of molecular sciences · 2025Review
- Unveiling the Impact of Peanut Consumption on Telomere Length in Young and Healthy Individuals: Insights from the ARISTOTLE Study: A Randomized Clinical Trial.Antioxidants (Basel, Switzerland) · 2025Article
- A Review of Botany, Phytochemistry, and Biological Activities of EightMolecules (Basel, Switzerland) · 2025Review
- Antioxidant activity and metabolic profile changes inFrontiers in nutrition · 2025Article
- Plant-derived compounds normalize platelet bioenergetics and function in hyperglycemia.Research and practice in thrombosis and haemostasis · 2024Article
- Evaluation of In Vitro-Derived Hop Plantlets, cv. Columbus and Magnum, as Potential Source of Bioactive Compounds.Antioxidants (Basel, Switzerland) · 2024Article
- Antioxidant activity of chia flour as a food supplement in a cellular model: Repercussions of processing andHeliyon · 2024Article
- Extraction of Bioactive Compounds FromInternational journal of food science · 2024Review
- 300-fold higher neuro- and immunotoxicity from low-redox transformation of carbamazepine.Toxicology reports · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The negative correlation between diets rich in fruits and vegetables and the occurrence of cardiovascular disease, stroke, cancer, atherosclerosis, cognitive impairment and other deleterious conditions is well established, with flavonoids and other polyphenols held to be partly responsible for the beneficial effects. Initially, these effects were explained by their antioxidant ability, but the low concentrations of polyphenols in tissues and relatively slow reaction with free radicals suggested that, instead, they act by regulating cell signalling pathways. Here we summarise results demonstrating that the abandonment of an antioxidant role for food polyphenols is based on incomplete knowledge of the mechanism of the polyphenol-free radical reaction. New kinetic measurements show that the reaction is up to 1000 times faster than previously reported and lowers the damaging potential of the radicals. The results also show that the antioxidant action does not require phenolic groups, but only a carbon-centred free radical and an aromatic molecule. Thus, not only food polyphenols but also many of their metabolites are effective antioxidants, significantly increasing the antioxidant protection of cells and tissues. By restoring an important antioxidant role for food polyphenols, the new findings provide experimental support for the advocacy of diets rich in plant-derived food.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.