Evidence map›Paper›PMID 34439499›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Quercetin Ameliorates Insulin Resistance and Restores Gut Microbiome in Mice on High-Fat Diets.

Yuqing Tan, Christina C Tam, Matt Rolston, Priscila Alves, Ling Chen, Shi Meng, Hui Hong, Sam K C Chang, Wallace Yokoyama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqing TanBeijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agriculture University, Beijing 100083, China.ORCID 0000-0003-2906-0026
Christina C TamFoodborne Toxins Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA.ORCID 0000-0003-1943-2762
Matt RolstonHost Microbe Systems Biology Core, University of California, One Shields Avenue, Davis, CA 95616, USA.
Priscila AlvesHealthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA.
Ling ChenHealthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA.
Shi MengNestlé R & D (China) Ltd., Beijing 100015, China.
Hui HongBeijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agriculture University, Beijing 100083, China.
Sam K C ChangExperimental Seafood Processing Laboratory, Costal Research and Extension Center, Mississippi State University, Biloxi, MS 39579, USA.
Wallace YokoyamaHealthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quercetin is a flavonoid that has been shown to have health-promoting capacities due to its potent antioxidant activity. However, the effect of chronic intake of quercetin on the gut microbiome and diabetes-related biomarkers remains unclear. Male C57BL/6J mice were fed HF or HF supplemented with 0.05% quercetin (HFQ) for 6 weeks. Diabetes-related biomarkers in blood were determined in mice fed high-fat (HF) diets supplemented with quercetin. Mice fed the HFQ diet gained less body, liver, and adipose weight, while liver lipid and blood glucose levels were also lowered. Diabetes-related plasma biomarkers insulin, leptin, resistin, and glucagon were significantly reduced by quercetin supplementation. In feces, quercetin supplementation significantly increased the relative abundance of

Indexed as

gut microbiomehigh-fat dietinsulin resistancequercetin

Identifiers

PMID34439499
PMCPMC8389224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.