Evidence map›Paper›PMID 34439497›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.

Catalina Londoño, Valerie Cayssials, Izar de Villasante, Marta Crous-Bou, Augustin Scalbert, Elisabete Weiderpass, Antonio Agudo, Anne Tjønneland, Anja Olsen, Kim Overvad and 23 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 19 institutions in 8 countries.

Catalina LondoñoUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Valerie CayssialsUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0003-4155-298X
Izar de VillasanteUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0001-7325-0631
Marta Crous-BouUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0003-1493-4288
Augustin ScalbertInternational Agency for Research on Cancer (IARC), 69372 Lyon, France.ORCID 0000-0001-6651-6710
Elisabete WeiderpassInternational Agency for Research on Cancer (IARC), 69372 Lyon, France.ORCID 0000-0003-2237-0128
Antonio AgudoUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Anne TjønnelandUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Anja OlsenUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.ORCID 0000-0003-4788-503X
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Matthias SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, 50139 Florence, Italy.ORCID 0000-0002-5558-2437
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.ORCID 0000-0003-0122-8624
Maria Santucci de MagistrisDepartment of Clinical and Experimental Medicine, Federico II University, 80138 Naples, Italy.
Rosario TuminoCancer Registry and Histopathology Unit, "Civic M.P. Arezzo" Hospital ASP, 97100 Ragusa, Italy.ORCID 0000-0003-2666-414X
Fulvio RicceriDepartment of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy.ORCID 0000-0001-8749-9737
Inger T GramDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway.ORCID 0000-0002-0031-4152
Charlotta RylanderDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway.
Guri SkeieDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway.ORCID 0000-0003-2476-4251
Maria-Jose SánchezEscuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain.ORCID 0000-0003-4817-0757
Pilar AmianoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
José María HuertaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.ORCID 0000-0002-9637-3869
Aurelio BarricarteCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
Hanna SartorDiagnostic Radiology Unit, Lund University, 20502 Malmö, Sweden.
Emily SonestedtNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, 21428 Malmö, Sweden.ORCID 0000-0002-0747-4562
Anders EsbergDepartment of Odontology, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0002-4430-8125
Annika IdahlDepartment of Clinical Sciences, Obstetrics and Gynecology, Umeå University, 90187 Umeå, Sweden.
Yahya Mahamat-SalehInstitut Gustave Roussy, 94805 Villejuif, France.ORCID 0000-0002-5892-8886
Nasser LaoualiInstitut Gustave Roussy, 94805 Villejuif, France.ORCID 0000-0002-8532-456X
Marina KvaskoffInstitut Gustave Roussy, 94805 Villejuif, France.ORCID 0000-0002-4557-3772
Renée Turzanski-FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Raul Zamora-RosUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Institut d'Investigació Biomédica de Bellvitge · ESInserm · FRUiT The Arctic University of Norway · NOCentre international de recherche sur le cancer · FRDanish Cancer Society · DKGerman Cancer Research Center · DELund University · SEUmeå University · SEAarhus University · DKAzienda Usl 8 Arezzo · ITBasque Government · ESFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ESUniversidad de Granada · ESUniversidad de la República de Uruguay · UYUniversity of Potsdam · DEUniversity of Turin · IT

Funding

Cancer Research UK 14136Medical Research Council MR/M012190/1World Health Organization 001
6 · The paper itself

Abstract

Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HR

Indexed as

cohortEPICflavonoidsintakeovarian cancerpolyphenols

Identifiers

PMID34439497
PMCPMC8389235
OpenAlexW3187302896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.