Evidence map›Paper›PMID 34439453›Full record

ReviewAntioxidants (Basel, Switzerland)2021

Scavenging Properties of Plant-Derived Natural Biomolecule Para-Coumaric Acid in the Prevention of Oxidative Stress-Induced Diseases.

Shubhadeep Roychoudhury, Barnali Sinha, Birupakshya Paul Choudhury, Niraj Kumar Jha, Partha Palit, Surekha Kundu, Subhash C Mandal, Adriana Kolesarova, Mokhtar Ibrahim Yousef, Janne Ruokolainen and 2 more

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  10. Development and Characterization ofLife (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shubhadeep RoychoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar 788011, India.ORCID 0000-0003-4174-1852
Barnali SinhaDepartment of Life Science and Bioinformatics, Assam University, Silchar 788011, India.
Birupakshya Paul ChoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar 788011, India.
Niraj Kumar JhaDepartment of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida 201310, India.ORCID 0000-0001-9486-4069
Partha PalitDepartment of Pharmaceutical Sciences, Assam University, Silchar 788011, India.ORCID 0000-0002-7544-391X
Surekha KunduDepartment of Botany, University of Calcutta, Kolkata 700019, India.
Subhash C MandalDepartment of Pharmaceutical Technology, Division of Pharmacognosy, Jadavpur University, Kolkata 700032, India.
Adriana KolesarovaFaculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.
Mokhtar Ibrahim YousefDepartment of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt.
Janne RuokolainenDepartment of Applied Physics, School of Science, Aalto University, 00076 Espoo, Finland.
Petr SlamaDepartment of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, 61300 Brno, Czech Republic.ORCID 0000-0003-0570-259X
Kavindra Kumar KesariDepartment of Applied Physics, School of Science, Aalto University, 00076 Espoo, Finland.ORCID 0000-0003-3622-9555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Para-coumaric acid (p-CA) is a plant derived secondary metabolite belonging to the phenolic compounds. It is widely distributed in the plant kingdom and found mainly in fruits, vegetables, and cereals. Various in vivo and in vitro studies have revealed its scavenging and antioxidative properties in the reduction of oxidative stress and inflammatory reactions. This evidence-based review focuses on the protective role of p-CA including its therapeutic potential. p-CA and its conjugates possesses various bioactivities such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, and anti-melanogenic properties. Due to its potent free radical scavenging activity, it can mitigate the ill effects of various diseases including arthritis, neurological disorders, and cardio-vascular diseases. Recent studies have revealed that p-CA can ameliorate the harmful effects associated with oxidative stress in the reproductive system, also by inhibiting enzymes linked with erectile function.

Indexed as

anti-canceranti-diabeticanti-inflammatoryanti-melanogenicantioxidantdiseaseoxidative stresspara-coumaric acidROS

Identifiers

PMID34439453
PMCPMC8388950

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.