Evidence map›Paper›PMID 34439438›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Left Ventricular SGLT1 Protein Expression Correlates with the Extent of Myocardial Nitro-Oxidative Stress in Rats with Pressure and Volume Overload-Induced Heart Failure.

Alex Ali Sayour, Mihály Ruppert, Attila Oláh, Kálmán Benke, Bálint András Barta, Eszter Zsáry, Haoran Ke, Eszter Mária Horváth, Béla Merkely, Tamás Radovits

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. SGLT1: A Potential Drug Target for Cardiovascular Disease.Drug design, development and therapy · 2023
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alex Ali SayourHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Mihály RuppertHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Attila OláhHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Kálmán BenkeHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Bálint András BartaHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Eszter ZsáryHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Haoran KeDepartment of Physiology, Semmelweis University, Tűzoltó Str. 37-47, H-1094 Budapest, Hungary.
Eszter Mária HorváthDepartment of Physiology, Semmelweis University, Tűzoltó Str. 37-47, H-1094 Budapest, Hungary.
Béla MerkelyHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.
Tamás RadovitsHeart and Vascular Center, Department of Cardiology, Semmelweis University, Városmajor Str. 68, H-1122 Budapest, Hungary.

Funding

Ministry for Innovation and Technology in Hungary Thematic Excellence Programme (2020-4.1.1.-TKP2020)Ministry of Human Capacities ÚNKP-20-4-II-SE-20National Research, Development and Innovation Fund of Hungary NVKP_16-1-2016-0017National Research, Development and Innovation Office (NKFIH) of Hungary K134939Semmelweis University EFOP-3.6.3-VEKOP-16-2017-00009
6 · The paper itself

Abstract

Myocardial sodium-glucose cotransporter 1 (SGLT1) has been shown to be upregulated in humans with heart failure (HF) with or without diabetes. In vitro studies have linked SGLT1 to increased nitro-oxidative stress in cardiomyocytes. We aimed to assess the relation between left ventricular (LV) SGLT1 expression and the extent of nitro-oxidative stress in two non-diabetic rat models of chronic heart failure (HF) evoked by either pressure (TAC,

Indexed as

heart failuremyocardial nitro-oxidative stressNADPH oxidase 4pressure overloadsodium-glucose cotransporter 1sodium-glucose cotransporter 2 inhibitorvolume overload

Identifiers

PMID34439438
PMCPMC8388925

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.