Evidence map›Paper›PMID 34439280›Full record

ArticleCancers2021

Pituitary Imaging Abnormalities and Related Endocrine Disorders in Erdheim-Chester Disease.

Skand Shekhar, Jorge A Irizarry-Caro, Ninet Sinaii, William A Gahl, Juvianee I Estrada-Veras, Rahul H Dave, Bernadette R Gochuico, Georgios Z Papadakis, Nicholas Patronas, Constantine A Stratakis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Neurological Manifestations of Histiocytic Disorders.Current neurology and neuroscience reports · 2023
    Review
  5. Survivorship Issues in Adult Patients With Histiocytic Neoplasms.Journal of the National Comprehensive Cancer Network : JNCCN · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Skand ShekharReproductive Physiology and Pathophysiology Group, Clinical Research Branch, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-9287-6664
Jorge A Irizarry-CaroOffice of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Ninet SinaiiClinical Center, NIH, Bethesda, MD 20892, USA.
William A GahlOffice of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Juvianee I Estrada-VerasOffice of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-2372-0372
Rahul H DaveDepartment of Neurology, Inova Fairfax- University of Virginia College of Medicine, Fairfax, VA 22031, USA.
Bernadette R GochuicoOffice of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-4727-8918
Georgios Z PapadakisDepartment of Radiology, Medical School, University of Crete, 71500 Heraklion, Greece.
Nicholas PatronasClinical Center, NIH, Bethesda, MD 20892, USA.
Constantine A StratakisSection on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Kevin O'BrienOffice of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Fady Hannah-ShmouniSection on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-6829-6205

Funding

Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development Intramural Research ProgramNHGRI NIH HHS Intramural Research ProgramNIEHS NIH HHS Intramural Research ProgramNIH Clinical Center Intramural Research ProgramNIH HHS Intramural Research Program
6 · The paper itself

Abstract

purposeWe examined abnormal pituitary imaging (API) and associated endocrine dysfunction in subjects with ECD.

methodsA cross-sectional descriptive examination of a natural history cohort study diagnosed with ECD was conducted at a clinical research center. Subjects underwent baseline endocrine tests of anterior and posterior pituitary function and dedicated pituitary gland MRI scans. We determined the frequency of various pituitary imaging abnormalities in ECD and assessed its relationships with age, sex, body mass index (BMI),

resultsOur cohort included 61 subjects with ECD [age (SD): 54.3 (10.9) y, 46 males/15 females]. API was present in 47.5% (29/61) of ECD subjects. Loss of the posterior pituitary bright spot (36.1%) followed by thickened pituitary stalk (24.6%), abnormal enhancement (18.0%), and pituitary atrophy (14.8%) were the most common abnormalities. DI and panhypopituitarism were more frequent in subjects with API without differences in age, sex distribution, hsCRP, ESR, and

conclusionsWe noted a high burden of API and endocrinopathies in ECD. API was highly associated with the presence of panhypopituitarism and DI. Therefore, a thorough assessment of hypothalamic-pituitary integrity should be considered in subjects with ECD.

Indexed as

diabetes insipidusendocrinologyErdheim–Chester diseasehistiocytosishypopituitarismhypothalamuspituitary

Identifiers

PMID34439280
PMCPMC8392147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.