Evidence map›Paper›PMID 34439257›Full record

ArticleCancers2021

Discontinuation of Imatinib in Children with Chronic Myeloid Leukemia: A Study from the International Registry of Childhood CML.

Frédéric Millot, Meinolf Suttorp, Stéphanie Ragot, Guy Leverger, Jean-Hugues Dalle, Caroline Thomas, Nathalie Cheikh, Brigitte Nelken, Marilyne Poirée, Geneviève Plat and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Targeted therapies in pediatric oncology: A start.Molecular therapy. Oncology · 2026
    Review
  6. Article
  7. EarlyCancers · 2025
    Article
  8. Review
  9. Article
  10. [How I treat pediatric chronic myeloid leukemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy.Case reports in oncological medicine · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 5 countries.

Frédéric MillotInserm CIC 1402, University Hospital of Poitiers, 86000 Poitiers, France.
Meinolf SuttorpMedical Faculty, Pediatric Hemato-Oncology, Technical University Dresden, 01307 Dresden, Germany.ORCID 0000-0002-9522-8838
Stéphanie RagotInserm CIC 1402, University Hospital of Poitiers, 86000 Poitiers, France.
Guy LevergerDepartment of Pediatric Hematology, Trousseau Hospital, 75012 Paris, France.
Jean-Hugues DalleDepartment of Pediatric Hematology, Robert Debré University Hospital, 75019 Paris, France.
Caroline ThomasDepartment of Pediatric Hematology, University Hospital of Nantes, 44000 Nantes, France.ORCID 0000-0002-3939-9317
Nathalie CheikhDepartment of Pediatric Hematology, University Hospital of Besançon, 25056 Besançon, France.
Brigitte NelkenDepartment of Pediatric Hematology, University Hospital of Lille, 59000 Lille, France.ORCID 0000-0003-1048-1517
Marilyne PoiréeDepartment of Pediatric Hematology, University Hospital of Nice, 06000 Nice, France.ORCID 0000-0001-5515-8794
Geneviève PlatDepartment of Pediatric Hematology, University Hospital of Toulouse, 31000 Toulouse, France.
Birgitta VersluysDepartment of Hematology, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
Birgitte LausenDepartment of Pediatrics, Rigshospitalet, 2100 Copenhagen, Denmark.
Marina BorisevichBelarusian Research Centre for Pediatric Oncology, Hematology and Immunology, 223053 Minsk, Belarus.ORCID 0000-0002-5180-5584
Inserm · FRBelarusian Research Center For Pediatric Oncology and Hematology · BYCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Nantes · FRHôpital Robert-Debré · FRLille’s Cardiology Hospital · FRRigshospitalet · DKTechnische Universität Dresden · DEUniversité Côte d'Azur · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within the International Registry of Childhood Chronic Myeloid Leukemia (CML), we identified 18 patients less than 18 years old at diagnosis of CML who were in the chronic phase and exhibiting a sustained deep molecular response (DMR) to imatinib defined as BCR-ABL1/ABL1 < 0.01% (MR

Indexed as

childrenchronic myeloid leukemiaimatinib

Identifiers

PMID34439257
PMCPMC8392145
OpenAlexW3194624016

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.