Evidence map›Paper›PMID 34439237›Full record

ArticleCancers2021

Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry.

Judith Gecht, Ioannis Tsoukakis, Kim Kricheldorf, Frank Stegelmann, Martine Klausmann, Martin Griesshammer, Holger Schulz, Wiebke Hollburg, Joachim R Göthert, Katja Sockel and 16 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  3. Renal Impairment in Myeloproliferative Neoplasms: An Under-reported Complication.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 16 institutions in 2 countries.

Judith GechtDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-9523-295X
Ioannis TsoukakisDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Kim KricheldorfDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-3102-2221
Frank StegelmannDepartment of Internal Medicine III, University Hospital of Ulm, 89081 Ulm, Germany.
Martine KlausmannStudienzentrum Aschaffenburg, 63739 Aschaffenburg, Germany.
Martin GriesshammerJohannes Wesling Medical Center, University Clinic for Hematology, Oncology, Hemostaseology, and Palliative Care (UKRUB), University of Bochum, 32429 Minden, Germany.
Holger SchulzOncological Practice, 50226 Frechen, Germany.
Wiebke HollburgHOPA-Hämatologisch-Onkologische Praxis Altona, 22767 Hamburg, Germany.
Joachim R GöthertDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, 45147 Essen, Germany.
Katja SockelMedical Clinic and Policlinic I, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
Florian H HeidelInnere Medizin C, Universitätsmedizin Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-2438-1955
Norbert GattermannCenter for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), 52074 Aachen, Germany.
Christoph MaintzMWZ-West Hematology-Oncology, 52146 Würselen, Germany.
Haifa K Al-AliDepartment of Hematology/Oncology, University Hospital Halle, 06120 Halle, Germany.
Uwe PlatzbeckerDepartment of Hematology and Cellular Therapy, Medical Clinic and Policlinic I, Leipzig University Hospital, 04103 Leipzig, Germany.ORCID 0000-0003-1863-3239
Richard HansenOncological Practice Dres. Hansen & Reeb, 67655 Kaiserslautern, Germany.
Mathias HänelDepartment of Internal Medicine III, Klinikum Chemnitz, 09116 Chemnitz, Germany.
Stefani ParmentierDepartment of Hematology and Oncology, Rems-Murr-Klinikum Winnenden, 71364 Winnenden, Germany.
Martin BommerDepartment of Hematology, Oncology, Infectious Diseases and Palliative Care, Alb-Fils-Kliniken, 73035 Göppingen, Germany.
Heike L PahlDepartment of Medicine I, Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Fabian LangDepartment of Medicine, Hematology/Oncology, Goethe-University, 60590 Frankfurt am Main, Germany.
Martin KirschnerDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Susanne IsfortDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Tim H BrümmendorfDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Konstanze DöhnerDepartment of Internal Medicine III, University Hospital of Ulm, 89081 Ulm, Germany.
Steffen KoschmiederDepartment of Hematology, Oncology, Hemostaseology and SCT, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1011-8171
RWTH Aachen University · DEGoethe University Frankfurt · DEUniversity Hospital Ulm · DEAlb Fils Kliniken · DEAschaffenburg University of Applied Sciences · DEEssen University Hospital · DEHeinrich Heine University Düsseldorf · DEKlinikum Chemnitz · DEPraxis für Hämatologie und Onkologie · DERems-Murr-Klinikum · DEUniversitätsmedizin Greifswald · DEUniversity Hospital Carl Gustav Carus · DEUniversity Hospital in Halle · DEUniversity Hospital Leipzig · DEUniversity Hospitals of the Ruhr-University of Bochum · DEUniversity of Freiburg · DE

Funding

PROBES OF ACTIN REGULATIONP01GM062566 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MITCHISON, TIMOTHY J · 2000 to 2004
$7.6M
Deutsche Forschungsgemeinschaft BR 1782/5-1Deutsche Forschungsgemeinschaft KO 2155/7-1Interdisciplinary Center for Clinical Research, Faculty of Medicine, RWTH Aachen University IZKF O3-7Stiftung Universitätsmedizin of RWTH Aachen University KK, THB, and SK
6 · The paper itself

Abstract

Inflammation-induced thrombosis represents a severe complication in patients with myeloproliferative neoplasms (MPN) and in those with kidney dysfunction. Overlapping disease-specific attributes suggest common mechanisms involved in MPN pathogenesis, kidney dysfunction, and thrombosis. Data from 1420 patients with essential thrombocythemia (ET, 33.7%), polycythemia vera (PV, 38.5%), and myelofibrosis (MF, 27.9%) were extracted from the bioregistry of the German Study Group for MPN. The total cohort was subdivided according to the calculated estimated glomerular filtration rate (eGFR, (mL/min/1.73 m

Indexed as

bleedingchronic kidney diseaseessential thrombocythemia (ET)JAK2V617Fmyeloproliferative neoplasms (MPN)polycythemia vera (PV)primary myelofibrosis (PMF)renal dysfunctionthromboembolismthrombosis

Identifiers

PMID34439237
PMCPMC8393882
OpenAlexW3195880766

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.