Evidence map›Paper›PMID 34439192›Full record

ArticleCancers2021

Protective and Therapeutic Effects of an IL-15:IL-15Rα-Secreting Cell-Based Cancer Vaccine Using a Baculovirus System.

Van Anh Do-Thi, Hayyoung Lee, Hye Jin Jeong, Jie-Oh Lee, Young Sang Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Van Anh Do-ThiDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Hayyoung LeeInstitute of Biotechnology, Chungnam National University, Daejeon 34134, Korea.
Hye Jin JeongDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Jie-Oh LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Young Sang KimDepartment of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea.

Funding

National Research Foundation of Korea 2019M3E5D6066058 and 2020R1F1A107312312
6 · The paper itself

Abstract

This study reports the use of the BacMam system to deliver and express self-assembling IL-15 and IL-15Rα genes to murine B16F10 melanoma and CT26 colon cancer cells. BacMam-based IL-15 and IL-15Rα were well-expressed and assembled to form the biologically functional IL-15:IL-15Rα complex. Immunization with this IL-15:IL-15Rα cancer vaccine delayed tumor growth in mice by inducing effector memory CD4

Indexed as

anticancerB16F10 melanomaCT-26cytokineinterleukin 15interleukin 15Rα

Identifiers

PMID34439192
PMCPMC8394727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.