Evidence map›Paper›PMID 34439187›Full record

ReviewCancers2021

Lung Cancer Surgery after Neoadjuvant Immunotherapy.

Dirk Stefani, Till Plönes, Jan Viehof, Kaid Darwiche, Martin Stuschke, Martin Schuler, Clemens Aigner

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Resectable non-stage IV nonsmall cell lung cancer: the surgical perspective.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  12. Article
  13. Article
  14. SUVmax-Δ makes the difference.Interactive cardiovascular and thoracic surgery · 2022
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dirk StefaniDepartment of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, Tueschener Weg 40, 45239 Essen, Germany.ORCID 0000-0001-5318-8113
Till PlönesDepartment of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, Tueschener Weg 40, 45239 Essen, Germany.
Jan ViehofDepartment of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, Tueschener Weg 40, 45239 Essen, Germany.
Kaid DarwicheDepartment of Pneumology, University Medicine Essen-Ruhrlandklinik, Tueschener Weg 40, 45239 Essen, Germany.ORCID 0000-0003-0681-1325
Martin StuschkeDepartment of Radiation Oncology, University Medicine Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Martin SchulerDepartment of Medical Oncology, University Medicine Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Clemens AignerDepartment of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, Tueschener Weg 40, 45239 Essen, Germany.ORCID 0000-0002-7787-991X
Ruhrlandklinik · DEEssen University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In early-stage lung cancer, recurrences are observed even after curative resection. Neoadjuvant immunotherapy might be a promising approach to eliminate micrometastasis and to potentially reduce recurrence rates and improve survival. Early trials have shown encouraging rates of pathologic response to neoadjuvant therapy and have demonstrated that surgery can be safely performed after neoadjuvant immunotherapy with various agents and in combination with chemo-(radio)therapy. However, whether these response rates translate into improved disease-free survival rates and overall survival rates remains to be determined by ongoing phase III studies.

Indexed as

lung cancer surgeryneoadjuvant immunotherapy

Identifiers

PMID34439187
PMCPMC8393473
OpenAlexW3191652336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.