Evidence map›Paper›PMID 34439132›Full record

ArticleCancers2021

A Humanized Anti-GPC3 Antibody for Immuno-Positron Emission Tomography Imaging of Orthotopic Mouse Model of Patient-Derived Hepatocellular Carcinoma Xenografts.

Arutselvan Natarajan, Hui Zhang, Wei Ye, Lakshmi Huttad, Mingdian Tan, Mei-Sze Chua, Sanjiv S Gambhir, Samuel K So

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applications.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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  15. Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma.American journal of nuclear medicine and molecular imaging · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arutselvan NatarajanMolecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9958-2623
Hui ZhangAsian Liver Center, Department of Surgery, School of Medicine, Stanford, CA 94305, USA.
Wei YeAsian Liver Center, Department of Surgery, School of Medicine, Stanford, CA 94305, USA.
Lakshmi HuttadAsian Liver Center, Department of Surgery, School of Medicine, Stanford, CA 94305, USA.
Mingdian TanAsian Liver Center, Department of Surgery, School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-3064-2189
Mei-Sze ChuaAsian Liver Center, Department of Surgery, School of Medicine, Stanford, CA 94305, USA.
Sanjiv S GambhirMolecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University, Stanford, CA 94305, USA.
Samuel K SoAsian Liver Center, Department of Surgery, School of Medicine, Stanford, CA 94305, USA.

Funding

Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
NCI NIH HHS U54 CA199075
6 · The paper itself

Abstract

Glypican-3 (GPC3) is an attractive diagnostic marker for hepatocellular carcinoma (HCC). We previously reported the potential of an

Indexed as

glypican-3hepatocellular carcinomahumanized antibodyimmunoPET imaging

Identifiers

PMID34439132
PMCPMC8391944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.