ArticleCancers2021
The Safety and Efficacy of Tranexamic Acid in Oncology Patients Undergoing Endoprosthetic Reconstruction and a ROTEM-Based Evaluation of Their Hemostatic Profile: A Pilot Study.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Tranexamic acid effectively reduces blood loss and transfusion requirements in musculoskeletal tumor surgery with acceptable safety: a systematic review and meta-analysis.EFORT open reviews · 2026Article
- Tranexamic Acid in Lower Extremity Endoprosthetic Reconstruction for Oncologic Indications: A Retrospective Comparative Study of 617 Patients.Journal of surgical oncology · 2026Article
- Does Topical Tranexamic Acid Facilitate Faster Discharge Following Lung Resection? A Retrospective Cohort Analysis.Journal of clinical medicine · 2026Article
- Efficacy of postoperative tranexamic acid administration in patients undergoing proximal femoral tumor endoprosthesis reconstruction.Perioperative medicine (London, England) · 2026Article
- Safety and efficacy of tranexamic acid in radical cystectomy: a systematic review and meta-analysis.Central European journal of urology · 2025Review
- Cancer-Associated Thrombosis: Pathophysiology, Laboratory Assessment, and Current Guidelines.Cancers · 2024Review
- The Safety and Efficacy of Microporous Polysaccharide Hemospheres in Terms of the Complication Rates in Total Hip Arthroplasty for Femoral Neck Fractures: A Control-Matched Retrospective Cohort.Life (Basel, Switzerland) · 2024Article
- The Hypercoagulable Profile of Patients with Bone Tumors: A Pilot Observational Study Using Rotational Thromboelastometry.Cancers · 2022Article
- The Non-Activated Thromboelastometry (NATEM) Assay's Application among Adults and Neonatal/Pediatric Population: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Antifibrinolytics use during surgery for oncological spine diseases: A systematic review.Surgical neurology international · 2022Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn endoprosthetic reconstruction in musculoskeletal oncology patients is associated with significant blood loss. The purpose of this study is to evaluate the safety and efficacy of tranexamic acid (TXA) for these patients and to assess any changes in their hemostatic profile using rotational thromboelastometry (ROTEM).
methodsA retrospective observational study was performed including 61 patients with primary or metastatic bone tumors who underwent surgery. Group A (
resultsThe median difference in blood loss between the two groups was 548.5 mL, indicating a 29.2% reduction in the 72 h blood loss following TXA administration (
conclusionTranexamic acid was associated with a significant reduction in perioperative blood loss and transfusion requirements without a complete shutdown of the fibrinolysis. Larger studies are warranted to assess the frequency of these outcomes in musculoskeletal oncology patients.
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