Evidence map›Paper›PMID 34439075›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Characterization and Clonal Diffusion of Ceftaroline Non-Susceptible MRSA in Two Hospitals in Central Italy.

Gianluca Morroni, Simona Fioriti, Federica Salari, Andrea Brenciani, Lucia Brescini, Marina Mingoia, Eleonora Giovanetti, Antonella Pocognoli, Andrea Giacometti, Elisa Molinelli and 3 more

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Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gianluca MorroniDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0003-0772-0214
Simona FioritiDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.
Federica SalariDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.
Andrea BrencianiDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0001-5191-3908
Lucia BresciniDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.
Marina MingoiaDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0001-8225-7843
Eleonora GiovanettiDepartment of Life and Environmental Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Antonella PocognoliClinical Microbiology Laboratory, "Ospedali Riuniti", 60126 Ancona, Italy.
Andrea GiacomettiDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.
Elisa MolinelliDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Annamaria OffidaniDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Oriana SimonettiDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.
Oscar CirioniDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCeftaroline represents a novel fifth-generation cephalosporin to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA).

methodsCeftaroline susceptibility of 239 MRSA isolates was assessed by disk diffusion and a MIC test strip following both EUCAST and CLSI guidelines. Non-susceptible isolates were epidemiologically characterized by pulsed-field gel electrophoresis, spa typing, and multilocus sequence typing, and further investigated by PCR and whole genome sequencing to detect penicillin-binding protein (PBP) mutations as well as antibiotic resistance and virulence genes.

resultsFourteen isolates out of two hundred and thirty-nine (5.8%) were non-susceptible to ceftaroline (MIC > 1 mg/L), with differences between the EUCAST and CLSI interpretations. The characterized isolates belonged to seven different pulsotypes and three different clones (ST228/CC5-t041-SCC

conclusionOur study demonstrated that ceftaroline non-susceptibile isolates belonged not only to ST228 strains (the most widespread clone in Italy) but also to ST22, confirming the increasing role of these clones in hospital infections.

Indexed as

ceftarolineMRSApenicillin-binding proteinsSCCmec

Identifiers

PMID34439075
PMCPMC8388857

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