Evidence map›Paper›PMID 34439066›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Thermal Shock and Ciprofloxacin Act Orthogonally on

Haydar Aljaafari, Yuejia Gu, Hannah Chicchelly, Eric Nuxoll

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Antibiotic Augmentation of Thermal Eradication ofPathogens (Basel, Switzerland) · 2024
    Article
  5. Temperature control in sepsis.Frontiers in medicine · 2023
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Haydar AljaafariDepartment of Chemical and Biochemical Engineering, 4133 Seamans Center for the Engineering Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-5051-4048
Yuejia GuDepartment of Chemical and Biochemical Engineering, 4133 Seamans Center for the Engineering Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.
Hannah ChicchellyDepartment of Chemical and Biochemical Engineering, 4133 Seamans Center for the Engineering Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.
Eric NuxollDepartment of Chemical and Biochemical Engineering, 4133 Seamans Center for the Engineering Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.
University of Iowa · US

Funding

Request for Funds to Purchase a Replacement Laser Scanning Confocal MicroscopeS10RR025439 · NCRR · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025439
6 · The paper itself

Abstract

Bacterial biofilm infections are a major liability of medical implants, due to their resistance to both antibiotics and host immune response. Thermal shock can kill established biofilms, and some evidence suggests antibiotics may enhance this efficacy, despite having an insufficient effect themselves. The nature of this interaction is unclear, however, complicating efforts to integrate thermal shock into implant infection treatment. This study aimed to determine whether these treatments were truly synergistic or simply orthogonal (i.e., independent).

Indexed as

antibacterial agentsbiofilmsciprofloxacinheat shockprosthesis-related infections

Identifiers

PMID34439066
PMCPMC8388990
OpenAlexW3194202056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.