Evidence map›Paper›PMID 34439056›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Metagenomics-Based Analysis of the Age-Related Cumulative Effect of Antibiotic Resistance Genes in Gut Microbiota.

Lei Wu, Xinqiang Xie, Ying Li, Tingting Liang, Haojie Zhong, Jun Ma, Lingshuang Yang, Juan Yang, Longyan Li, Yu Xi and 5 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lei WuSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID 0000-0001-6553-6322
Xinqiang XieGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Ying LiGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Tingting LiangSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Haojie ZhongThe First Affiliated Hospital, School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, China.ORCID 0000-0001-6586-756X
Jun MaSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Lingshuang YangGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Juan YangSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Longyan LiGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Yu XiGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Haixin LiGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Jumei ZhangGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Xuefeng ChenSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Yu DingDepartment of Food Science and Technology, Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-3688-7294
Qingping WuGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.ORCID 0000-0001-6503-359X

Funding

Guangdong Province Academy of Sciences Special Project for Capacity Building of Innovation Driven Development 2020GDASYL-20200301002Key-Area Research and Development Program of Guangdong Province 2018B020205002Project by the Department of Science and Technology of Guangdong Province 2019QN01N107
6 · The paper itself

Abstract

Antibiotic resistance in bacteria has become a major global health problem. One of the main reservoirs of antibiotic resistance genes is the human gut microbiota. To characterise these genes, a metagenomic approach was used. In this study, a comprehensive antibiotic resistome catalog was established using fecal samples from 246 healthy individuals from world's longevity township in Jiaoling, China. In total, 606 antibiotic resistance genes were detected. Our results indicated that antibiotic resistance genes in the human gut microbiota accumulate and become more complex with age as older groups harbour the highest abundance of these genes. Tetracycline resistance gene type

Indexed as

antibiotic resistance genescumulative effectgut microbiotalongevity peoplemetagenomics

Identifiers

PMID34439056
PMCPMC8388928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.