Evidence map›Paper›PMID 34439019›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Flavonoid-Coated Gold Nanoparticles as Efficient Antibiotics against Gram-Negative Bacteria-Evidence from In Silico-Supported In Vitro Studies.

Hani A Alhadrami, Raha Orfali, Ahmed A Hamed, Mohammed M Ghoneim, Hossam M Hassan, Ahmed S I Hassane, Mostafa E Rateb, Ahmed M Sayed, Noha M Gamaleldin

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  4. Article
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  6. Article
  7. Review
  8. Tackling carbapenem-resistantBiotechnology notes (Amsterdam, Netherlands) · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Wild-Grown RomanianPlants (Basel, Switzerland) · 2023
    Article
  19. Green Synthesis of Zinc Oxide Nanoparticles UsingPlants (Basel, Switzerland) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 3 countries.

Hani A AlhadramiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-4822-1895
Raha OrfaliDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Ahmed A HamedNational Research Centre, Microbial Chemistry Department, 33 El-Buhouth Street, Dokki, Giza P.O. Box 12622, Egypt.
Mohammed M GhoneimDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia.ORCID 0000-0002-9179-4373
Hossam M HassanDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.
Ahmed S I HassaneSchool of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.
Mostafa E RatebSchool of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.ORCID 0000-0003-4043-2687
Ahmed M SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.ORCID 0000-0002-1442-183X
Noha M GamaleldinDepartment of Microbiology, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo 11837, Egypt.ORCID 0000-0002-0611-651X
Aberdeen Royal Infirmary · GBAlmaarefa UniversityBeni-Suef University · EGBritish University in Egypt · EGKing Abdulaziz University · SAKing Saud University · SANahda University · EGNational Research Centre · EGUniversity of the West of Scotland · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonoids are a class of bioactive plant-derived natural products that exhibit a broad range of biological activities, including antibacterial ones. Their inhibitory activity toward Gram-positive bacterial was found to be superior to that against Gram-negative ones. In the present study, a number of flavonoid-coated gold nanoparticles (GNPs) were designed to enhance the antibacterial effects of chrysin, kaempferol, and quercetin against a number of Gram-negative bacteria. The prepared GNPs were able to conjugate to these three flavonoids with conjugation efficiency ranging from 41% to 80%. Additionally, they were able to exert an enhanced antibacterial activity in comparison with the free flavonoids and the unconjugated GNPs. Quercetin-coated GNPs were the most active nano-conjugates and were able to penetrate the cell wall of

Indexed as

DNA gyraseflavonoidsgold nanoparticlesGram-negative bacteriain silico

Identifiers

PMID34439019
PMCPMC8389009
OpenAlexW3187379372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.