Evidence map›Paper›PMID 34439002›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Cyclic and Acyclic Amine Oxide Alkyl Derivatives as Potential Adjuvants in Antimicrobial Chemotherapy against Methicillin-Resistant

Lorenza Fagnani, Lisaurora Nazzicone, Fabrizia Brisdelli, Luisa Giansanti, Sara Battista, Roberto Iorio, Sabrina Petricca, Gianfranco Amicosante, Mariagrazia Perilli, Giuseppe Celenza and 1 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Medicinal Chemistry of Drugs withJournal of medicinal chemistry · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Structurally Related Liposomes ContainingMolecular pharmaceutics · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lorenza FagnaniDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Lisaurora NazziconeDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Fabrizia BrisdelliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Luisa GiansantiDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.ORCID 0000-0001-9056-0607
Sara BattistaDepartment of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Roberto IorioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.ORCID 0000-0003-1863-5752
Sabrina PetriccaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.ORCID 0000-0002-9794-3632
Gianfranco AmicosanteDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Mariagrazia PerilliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.ORCID 0000-0001-7370-1455
Giuseppe CelenzaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.
Pierangelo BellioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.ORCID 0000-0001-6488-8027

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dramatic intensification of antimicrobial resistance occurrence in pathogenic bacteria concerns the global community. The revitalisation of inactive antibiotics is, at present, the only way to go through this health system crisis and the use of antimicrobial adjuvants is turning out the most promising approach. Due to their low toxicity, eco-friendly characteristics and antimicrobial activity, amphoteric surfactants are good candidates. This study investigated the adjuvant potentialities of commercial acyclic and newly cyclic

Indexed as

adjuvantsamine oxidesamphoteric surfactantsantibioticscheckerboard assaycytotoxicityMRSAmultidrug resistance

Identifiers

PMID34439002
PMCPMC8388947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.