ArticleAntibiotics (Basel, Switzerland)2021
Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study.
Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The effects of environmentally relevant concentrations of enrofloxacin on growth performance, oxidative stress, and mRNA expression of apoptotic enzymes (caspase-3, caspase-8)/pro-inflammatory cytokines (IL-1β, TNF-β, and IL-6) in gills of Oreochromis niloticus.Fish physiology and biochemistry · 2025Article
- Environmental Footprint of Antibiotics: A Multi-Source Investigation of Wastewater Systems in UAE.Antibiotics (Basel, Switzerland) · 2025Article
- Biotransformation of Antibiotics byAntibiotics (Basel, Switzerland) · 2025Article
- Preparation of MOF-5 imprinted chromium ferrite and its application in decontaminating metronidazole and penicillin G contaminated water system.Scientific reports · 2025Article
- Evaluating Arundo donax efficiency for pharmaceutical compounds removal from synthetic wastewater in horizontal flow constructed wetland.Scientific reports · 2025Article
- Future Healthcare Workers and Ecopharmacovigilance: Where Do We Stand?Pharmacy (Basel, Switzerland) · 2024Article
- Environmental risk of diclofenac in European groundwaters and implications for environmental quality standards.Scientific reports · 2024Article
- Tackling Carbapenem Resistance and the Imperative for One Health Strategies-Insights from the Portuguese Perspective.Antibiotics (Basel, Switzerland) · 2024Review
- Predicted Environmental Risk Assessment of Antimicrobials with Increased Consumption in Portugal during the COVID-19 Pandemic; The Groundwork for the Forthcoming Water Quality Survey.Antibiotics (Basel, Switzerland) · 2023Article
- Synthesis of neodymium ferrite incorporated graphitic carbonitride (NdFeRSC advances · 2023Article
- Outstanding Enrofloxacin Removal Using an Unmodified Low-Cost Sorbent Prepared from the Leaves ofAntibiotics (Basel, Switzerland) · 2022Article
- Recovery of the Structure and Function of the Pig Manure Bacterial Community after Enrofloxacin Exposure.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Environmental monitoring, particularly of water, is crucial to screen and preselect potential hazardous substances for policy guidance and risk minimisation strategies. In Portugal, extensive data are missing. This work aimed to perform a qualitative survey of antibiotics in surface- groundwater, reflecting demographic, spatial, consumption and drug profiles during an observational period of three years. A passive sampling technique (POCIS) and high-resolution chromatographic system were used to monitor and analyse the antibiotics. The most frequently detected antibiotics were enrofloxacin/ciprofloxacin and tetracycline in surface-groundwater, while clarithromycin/erythromycin and sulfamethoxazole were identified only in surface water. The detection of enzyme inhibitors (e.g., tazobactam/cilastatin) used exclusively in hospitals and abacavir, a specific human medicine was also noteworthy. North (Guimarães, Santo Tirso and Porto) and South (Faro, Olhão and Portimão) Portugal were the regions with the most significant frequency of substances in surface water. The relatively higher detection downstream of the effluent discharge points compared with a low detection upstream could be attributed to a low efficiency in urban wastewater treatment plants and an increased agricultural pressure. This screening approach is essential to identify substances in order to perform future quantitative risk assessment and establishing water quality standards. The greatest challenge of this survey data is to promote an ecopharmacovigilance framework, implement measures to avoid misuse/overuse of antibiotics and slow down emission and antibiotic resistance.
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