Evidence map›Paper›PMID 34438836›Full record

ArticleAnimals : an open access journal from MDPI2021

Establishment and Characterization of Feline Mammary Tumor Patient-Derived Xenograft Model.

Hsiao-Li Chuang, Yi-Chih Chang, Yi-Ting Huang, Jiunn-Wang Liao, Pei-Ling Kao, Yi-Fei Chen, Bin-Yin Lin, Yi-Lo Lin, Ter-Hsin Chen, Yu-Chih Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hsiao-Li ChuangNational Laboratory Animal Center, National Applied Research Laboratories, Taipei 106214, Taiwan.ORCID 0000-0002-3718-9076
Yi-Chih ChangDepartment of Biotechnology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
Yi-Ting HuangGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.
Jiunn-Wang LiaoGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0001-7374-1203
Pei-Ling KaoGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.
Yi-Fei ChenGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.
Bin-Yin LinGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.
Yi-Lo LinGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.
Ter-Hsin ChenGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.
Yu-Chih WangGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0003-0144-1388

Funding

Ministry of Science and Technology MOST106-2313-B-005 -059 - and MOST107-2311-B-005 -011 -MY3
6 · The paper itself

Abstract

Feline mammary tumor is a relatively commonly diagnosed neoplasm in the cat. Development of new veterinary cancer therapies is limited by the shortage of in vivo models that reproduce tumor microenvironment and metastatic progression. Four feline mammary tumor orthotopic patient-derived xenograft model (PDX) successfully established in NOD-SCID gamma (NSG) mice. The overall success rate of PDX establishment was 36% (4/11). Histological, immunohistochemical, and short tandem repeat analysis showed a remarkable similarity between patient's tumor and xenograft. The tumor grafts conserve original tumor essential features, including distant metastasis. Primary FMT-1807 cell line isolated from FMT-1807PDX tumor tissue. Tumorigenicity of FMT-1807 cells expanded from PDX was assessed by orthotopic injection into NSG mice. Mice yielded tumors which preserve the lung and liver metastasis ability. This work provides a platform for FMT translational investigation.

Indexed as

cell linefeline mammary tumorpatient-derived xenograft

Identifiers

PMID34438836
PMCPMC8388766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.