Evidence map›Paper›PMID 34438784›Full record

ArticleAnimals : an open access journal from MDPI2021

All the Pups We Cannot See: Cannibalism Masks Perinatal Death in Laboratory Mouse Breeding but Infanticide Is Rare.

Sophie Brajon, Gabriela Munhoz Morello, Sara Capas-Peneda, Jan Hultgren, Colin Gilbert, Anna Olsson

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Killing behaviors in rodents: from predation to infanticide.Frontiers in behavioral neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Sophie BrajonLaboratory Animal Science, IBMC-Instituto de Biologia Molecular e Celular, and i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0003-2951-9888
Gabriela Munhoz MorelloLaboratory Animal Science, IBMC-Instituto de Biologia Molecular e Celular, and i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0002-5439-969X
Sara Capas-PenedaLaboratory Animal Science, IBMC-Instituto de Biologia Molecular e Celular, and i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0002-0167-8812
Jan HultgrenDepartment of Animal Environment and Health, Swedish University of Agricultural Sciences, 53223 Skara, Sweden.ORCID 0000-0001-9164-2321
Colin GilbertBabraham Institute, Babraham, Cambridge CB22 3AT, UK.
Anna OlssonLaboratory Animal Science, IBMC-Instituto de Biologia Molecular e Celular, and i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0002-4369-8723
Babraham Institute · GBi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTSwedish University of Agricultural Sciences · SEUniversidade do Porto · PT

Funding

European Regional Development Fund POCI-01-0145-FEDER-016591Fundação para a Ciência e a Tecnologia PTDC/CVT-WEL/1202/2014
6 · The paper itself

Abstract

Perinatal mortality is a major issue in laboratory mouse breeding. We compared a counting method using daily checks (DAILY_CHECK) with a method combining daily checks with detailed video analyses to detect cannibalisms (VIDEO_TRACK) for estimating the number of C57BL/6 pups that were born, that died and that were weaned in 193 litters from trios with (TRIO-OVERLAP) or without (TRIO-NO_OVERLAP) the presence of another litter. Linear mixed models were used at litter level. To understand whether cannibalism was associated with active killing (infanticide), we analysed VIDEO_TRACK recordings of 109 litters from TRIO-OVERLAP, TRIO-NO_OVERLAP or SOLO (single dams). We used Kaplan-Meier method and logistic regression at pup level. For DAILY_CHECK, the mean litter size was 35% smaller than for VIDEO_TRACK (

Indexed as

3Rs principleasynchrony breedingcage inspectioncannibalistic behaviourhusbandry practicesmouse welfareneonatal mortalitypup-counting methodsocial environment

Identifiers

PMID34438784
PMCPMC8388445
OpenAlexW3175817440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.