Evidence map›Paper›PMID 34438625›Full record

ReviewAnimals : an open access journal from MDPI2021

The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish.

Ehsan Ahmadifar, Hamideh Pourmohammadi Fallah, Morteza Yousefi, Mahmoud A O Dawood, Seyed Hossein Hoseinifar, Hossein Adineh, Sevdan Yilmaz, Marina Paolucci, Hien Van Doan

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. The Effect of Low-Fishmeal Feed Including an Olive Leaf Extract (Animals : an open access journal from MDPI · 2026
    Article
  3. Molecules (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Frontiers in immunology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Yellow mealworm (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Article
  18. Article
  19. Pathogens (Basel, Switzerland) · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ehsan AhmadifarDepartment of Fisheries, Faculty of Natural Resources, University of Zabol, Zabol 98613-35856, Iran.
Hamideh Pourmohammadi FallahDepartment of Medicine, University of British Columbia, Vancouver, BC V1Y 1T3, Canada.
Morteza YousefiDepartment of Veterinary Medicine, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, 117198 Moscow, Russia.ORCID 0000-0001-5352-8106
Mahmoud A O DawoodDepartment of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0002-4887-8838
Seyed Hossein HoseinifarDepartment of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan 4918943464, Iran.ORCID 0000-0002-0210-9013
Hossein AdinehDepartment of Fisheries, Faculty of Ariculture and Natural Resources, Gonbad Kavous University, Gonbad Kavous, Golestan 4971799151, Iran.
Sevdan YilmazDepartment of Aquaculture, Faculty of Marine Sciences and Technology, Canakkale Onsekiz Mart University, Canakkale 17100, Turkey.ORCID 0000-0002-4809-5809
Marina PaolucciDepartment of Science and Technologies, University of Sannio, 82100 Benevento, Italy.ORCID 0000-0002-1784-3843
Hien Van DoanDepartment of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand.

Funding

Chiang Mai University none
6 · The paper itself

Abstract

The crucial need for safe and healthy aquatic animals obligates researchers in aquaculture to investigate alternative and beneficial additives. Medicinal herbals and their extracts are compromised with diverse effects on the performances of aquatic animals. These compounds can affect growth performance and stimulate the immune system when used in fish diet. In addition, the use of medicinal herbs and their extracts can reduce oxidative stress induced by several stressors during fish culture. Correspondingly, aquatic animals could gain increased resistance against infectious pathogens and environmental stressors. Nevertheless, the exact mode of action where these additives can affect aquatic animals' performances is still not well documented. Understanding the mechanistic role of herbal supplements and their derivatives is a vital tool to develop further the strategies and application of these additives for feasible and sustainable aquaculture. Gene-related studies have clarified the detailed information on the herbal supplements' mode of action when administered orally in aquafeed. Several review articles have presented the potential roles of medicinal herbs on the performances of aquatic animals. However, this review article discusses the outputs of studies conducted on aquatic animals fed dietary, medicinal herbs, focusing on the gene expression related to growth and immune performances. Furthermore, a particular focus is directed to the expected influence of herbal supplements on the reproduction of aquatic animals.

Indexed as

aquaculturegene regulationsgrowthherbal extractsimmunity

Identifiers

PMID34438625
PMCPMC8388479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.