ArticleChildren (Basel, Switzerland)2021
Biomarkers of Allostatic Load as Correlates of Impairment in Youth with Chronic Pain: An Initial Investigation.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Investigating associations between allostatic load phenotypes and clinical impairment in youth with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Changes in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study.Pain reports · 2026Article
- Neuroinflammation and Pediatric Chronic Pain - A Review.Current pain and headache reports · 2026Review
- Expanding the Lens: Recent Developments at the Intersection of Pediatric Chronic Pain and Gender Diversity.Current pain and headache reports · 2025Review
- Using fast periodic visual stimulation to investigate the processing of health-related images in the human brain.Scientific reports · 2025Article
- Disparities in Allostatic Load Among Different Races: A Comprehensive Scoping Review.Journal of racial and ethnic health disparities · 2025Review
- Use of Over-The-Counter Analgesics Is Associated with Pain, Stress, and Quality of Life in Norwegian Adolescents: A Cross-Sectional Study.Children (Basel, Switzerland) · 2024Article
- Allostatic load and chronic pain: a prospective finding from the national survey of midlife development in the United States, 2004-2014.BMC public health · 2024Article
- Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders.PloS one · 2024Article
- Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.Journal of clinical medicine · 2023Article
- Narrative Review of the Complex Interaction between Pain and Trauma in Children: A Focus on Biological Memory, Preclinical Data, and Epigenetic Processes.Children (Basel, Switzerland) · 2023Review
- Increased hippocampal efficiency is associated with greater headache frequency in adolescents with chronic headache.Cerebral cortex communications · 2023Article
- The impact of adverse childhood experiences and posttraumatic stress symptoms on chronic pain.Frontiers in psychology · 2023Article
- Case report: Chronic pain in a pediatric patient with late-onset pompe disease.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Hippocampal volume changes across developmental periods in female migraineurs.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Pediatric chronic pain is common and responsible for significant healthcare burden. However, the mechanisms underlying the development and/or maintenance of pediatric chronic pain remain poorly understood. Allostatic load (AL), or wear and tear on the nervous system following significant or prolonged stress, has been proposed to play a role in the maintenance of chronic pain, but minimal research has examined this possibility. This gap in research is particularly notable given the high exposure to adverse childhood experiences (ACEs; abuse/neglect, etc.) and psychological stress in this population. Accordingly, the current study aimed to preliminarily examine the measurement of AL in a treatment-seeking pediatric pain population. Biomarkers were collected during an already scheduled new patient pain evaluation and included salivary cortisol, dehydroepiandrosterone (DHEA), and C-reactive protein, in addition to waist-hip ratio, body-mass index, and blood pressure. A total of 61 children and adolescents with chronic pain (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.