Evidence map›Paper›PMID 34438599›Full record

ReviewChildren (Basel, Switzerland)2021

The Role of Environmental Risk Factors on the Development of Childhood Allergic Rhinitis.

Allison C Wu, Amber Dahlin, Alberta L Wang

Open access · goldAbstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases.World journal of otorhinolaryngology - head and neck surgery · 2026
    Review
  3. Review
  4. Article
  5. Development and validation of a clinical risk prediction model for chronic sinusitis with nasal polyps: a retrospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. [Analysis of allergen distribution and indoor factors in allergic rhinitis in Chaoshan area].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Allison C WuChanning Division of Network Medicine, Mass General Brigham, Boston, MA 02115, USA.
Amber DahlinChanning Division of Network Medicine, Mass General Brigham, Boston, MA 02115, USA.
Alberta L WangChanning Division of Network Medicine, Mass General Brigham, Boston, MA 02115, USA.ORCID 0000-0002-2151-4823
Mass General Brigham · US

Funding

Pharmacogenomics of Adrenal Suppression with Inhaled Corticosteroids (PhASIC)R01HL152244 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DAHLIN, AMBER · 2020 to 2024
$4.4M
Clinical prediction and epigenetic regulation of asthma and rhinitisK23HL151819 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, ALBERTA L. · 2021 to 2023
$639k
NHLBI NIH HHS K23 HL151819NHLBI NIH HHS R01 HL152244NIAID NIH HHS L40 AI138248
6 · The paper itself

Abstract

Environmental factors play an important role in the development and exacerbation of allergic rhinitis (AR) in childhood. Indoor air pollution, such as house dust mites and secondhand smoke, can significantly increase the onset of AR, while pet dander may affect the exacerbation of AR symptoms in children. Furthermore, traffic related air pollution and pollen are outdoor air pollutants that can affect immune competency and airway responsiveness, increasing the risk of AR in children. Climate change has increased AR in children, as growth patterns of allergenic species have changed, resulting in longer pollen seasons. More extreme and frequent weather events also contribute to the deterioration of indoor air quality due to climate change. Additionally, viruses provoke respiratory tract infections, worsening the symptoms of AR, while viral infections alter the immune system. Although viruses and pollution influence development and exacerbation of AR, a variety of treatment and prevention options are available for AR patients. The protective influence of vegetation (greenness) is heavily associated with air pollution mitigation, relieving AR exacerbations, while the use of air filters can reduce allergic triggers. Oral antihistamines and intranasal corticosteroids are common pharmacotherapy for AR symptoms. In this review, we discuss the environmental risk factors for AR and summarize treatment strategies for preventing and managing AR in children.

Indexed as

air pollutionallergensallergic rhinitischildclimate changegreennesspediatricspreventiontherapeuticstobacco smoketraffic related air pollutionviruses

Identifiers

PMID34438599
PMCPMC8391414
OpenAlexW3195154834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.