Evidence map›Paper›PMID 34438593›Full record

ArticleChildren (Basel, Switzerland)2021

Type 1 Diabetes and Addison's Disease: When the Diagnosis Is Suggested by the Continuous Glucose Monitoring System.

Francesco Vinci, Giuseppe d'Annunzio, Flavia Napoli, Marta Bassi, Carolina Montobbio, Giulia Ferrando, Nicola Minuto

Abstract readCase Reports
In one paragraph

Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco VinciDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genova, Italy.ORCID 0000-0003-3693-1555
Giuseppe d'AnnunzioDepartment of Pediatric Clinic and Endocrinology, Regional Center for Pediatric Diabetes, IRCCS Giannina Gaslini, 16147 Genoa, Italy.
Flavia NapoliDepartment of Pediatric Clinic and Endocrinology, Regional Center for Pediatric Diabetes, IRCCS Giannina Gaslini, 16147 Genoa, Italy.
Marta BassiDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genova, Italy.ORCID 0000-0002-9166-1079
Carolina MontobbioDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genova, Italy.
Giulia FerrandoDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genova, Italy.
Nicola MinutoDepartment of Pediatric Clinic and Endocrinology, Regional Center for Pediatric Diabetes, IRCCS Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-5280-6319

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our objective is to emphasize the important role of continuous glucose monitoring (CGM) in suggesting adrenal insufficiency in patients affected by type 1 diabetes. We describe an adolescent girl with type 1 diabetes and subsequent latent Addison's disease diagnosed based on a recurrent hypoglycemic trend detected by CGM. In patients with type 1 diabetes, persistent unexplained hypoglycemic episodes at dawn together with reduced insulin requirement arouse souspicionof adrenal insufficiency. Adrenal insufficiency secondary to autoimmune Addison's disease, even if rarely encountered among young patients, may be initially symptomless and characterized by slow progression up to acute adrenal crisis, which represents a potentially life-threatening condition. Besides glycometabolic assessment and adequate insulin dosage adjustment, type 1 diabetes needs prompt recognition of potentially associated autoimmune conditions. Among these, Addison's disease can be suspected, although latent or paucisymptomatic, through periodic and careful evaluation of CGM data.

Indexed as

adrenal insufficiencycontinuous glucose monitoringhypoglycemiaSchmidt’s syndrometype 1 diabetes

Identifiers

PMID34438593
PMCPMC8391923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.