Evidence map›Paper›PMID 34438546›Full record

ArticleChildren (Basel, Switzerland)2021

Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease.

Michela Vergine, Luca Vedovelli, Manuela Simonato, Valentina Tonazzo, Alessio Correani, Elisa Cainelli, Dario Gregori, Massimo A Padalino, Paola Cogo

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In one paragraph

Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michela VergineDivision of Pediatrics, Department of Medicine, University Hospital S Maria della Misericordia, University of Udine, Piazzale Santa Maria della Misericordia, 15, 33100 Udine, Italy.
Luca VedovelliUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan, 18, 35131 Padova, Italy.ORCID 0000-0003-4847-2333
Manuela SimonatoPCare Laboratory, Fondazione Istituto di Ricerca Pediatrica, "Citta' della Speranza", Corso Stati Uniti, 4F, 35127 Padova, Italy.ORCID 0000-0002-2745-7305
Valentina TonazzoDepartment of Women's and Children's Health, University of Padova, Via Giustiniani, 3, 35128 Padova, Italy.
Alessio CorreaniDivision of Neonatology, Polytechnic University of Marche and "G. Salesi" Children's Hospital, Via Corridoni, 11, 60123 Ancona, Italy.
Elisa CainelliDepartment of General Psychology, University of Padova, Via Venezia, 8, 35131 Padova, Italy.ORCID 0000-0002-5039-4680
Dario GregoriUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan, 18, 35131 Padova, Italy.ORCID 0000-0001-7906-0580
Massimo A PadalinoPediatric and Congenital Cardiac Surgery, Department of Cardiac-Thoracic-Vascular Sciences and Publich Health, University of Padova, Via Giustiniani, 2-35128 Padova, Italy.ORCID 0000-0002-7535-9670
Paola CogoDepartment of Medicine, University Hospital S Maria della Misericordia, University of Udine, Piazzale Santa Maria della Misericordia, 15, 33100 Udine, Italy.

Funding

Just Foundation grant 2016 . 2016Umberto Veronesi Foundation 2017
6 · The paper itself

Abstract

backgroundBrain injury, impaired brain maturation, and long-term neurodevelopmental disorders are common in infants with congenital heart diseases (CHD). We aimed to assess whether plasma glial fibrillary acidic protein (GFAP) can predict neurodevelopmental anomalies in CHD infants operated on cardiopulmonary bypass (CPB).

methodsWe measured plasma GFAP in 38 infants at multiple CPB phases. Cognitive, neuropsychological, and psychopathological functioning were assessed 5.7 ± 2.2 years after surgery. We identified an impaired global neurodevelopmental index (NDI) when at least two domains were abnormal. The relationships between NDI, GFAP, and clinical variables were explored with non-supervised feature selection methods and modeled with a nested non-linear logistic regression.

resultsIntelligence quotient scores were within the normal range in 84% of children, whereas 58% showed an abnormal NDI, with the greatest impairments in the psychopathological area. The plasma GFAP peak was 0.95 (0.44-1.57) ng/mL, and it was correlated with age, weight, duration of surgery phases, and CPB minimum temperature. In the regression model, the GFAP peak was associated with an impaired NDI with a possible flexible point toward NDI impairment at 0.49 ng/mL, keeping constant ICU stay, CPB duration, CHD anatomy, weight, and CPB minimum temperature.

conclusionGFAP is a promising early marker of abnormal long-term neuropsychological development.

Indexed as

cardiopulmonary bypasschildrencongenital heart diseaseglial fibrillary acidic proteinneuropsychological outcome

Identifiers

PMID34438546
PMCPMC8391328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.